| Cerebral vasculitis associated with cocaine abuse. | |
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MedLine Citation:
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PMID: 1750054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Earlier reports of cocaine-associated cerebral vasculitis have been based primarily on angiographic findings without pathological verification. CASE DESCRIPTION: We present a case of acute encephalopathy following intravenous and intranasal administration of cocaine. Brain biopsy revealed vascular changes involving primarily small arteries. Findings included lymphocytic infiltration, endothelial thickening, and deposition of proteinaceous amorphous material within and around vessel walls. CONCLUSIONS: These abnormalities are consistent with pathological features of arteritis previously reported in association with amphetamine and multiple-drug abuse. Vasospasm-induced changes are an alternative explanation for the vascular picture seen in this case. The patient made modest improvement with high-dose intravenous steroids. |
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Authors:
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R K Fredericks; D S Lefkowitz; V R Challa; B T Troost |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 22 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1992-01-22 Completed Date: 1992-01-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1437-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27103. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Brain / pathology Cerebrovascular Disorders / etiology*, pathology Cocaine* Female Humans Substance-Related Disorders / complications* Vasculitis / etiology*, pathology |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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