Document Detail

Cerebral vasculitis associated with cocaine abuse.
MedLine Citation:
PMID:  1750054     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Earlier reports of cocaine-associated cerebral vasculitis have been based primarily on angiographic findings without pathological verification. CASE DESCRIPTION: We present a case of acute encephalopathy following intravenous and intranasal administration of cocaine. Brain biopsy revealed vascular changes involving primarily small arteries. Findings included lymphocytic infiltration, endothelial thickening, and deposition of proteinaceous amorphous material within and around vessel walls. CONCLUSIONS: These abnormalities are consistent with pathological features of arteritis previously reported in association with amphetamine and multiple-drug abuse. Vasospasm-induced changes are an alternative explanation for the vascular picture seen in this case. The patient made modest improvement with high-dose intravenous steroids.
R K Fredericks; D S Lefkowitz; V R Challa; B T Troost
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  22     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-01-22     Completed Date:  1992-01-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1437-9     Citation Subset:  IM    
Department of Neurology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27103.
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MeSH Terms
Brain / pathology
Cerebrovascular Disorders / etiology*,  pathology
Substance-Related Disorders / complications*
Vasculitis / etiology*,  pathology
Reg. No./Substance:

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