Document Detail

Cerebral vascular reactivity to carbon dioxide before and after cardiopulmonary bypass in children with congenital heart disease.
MedLine Citation:
PMID:  8231203     Owner:  NLM     Status:  MEDLINE    
We examined cerebral vascular reactivity to carbon dioxide before and after cardiopulmonary bypass in 15 pediatric patients aged 2 to 9 years undergoing cardiac operations. Cerebral vascular reactivity was noninvasively assessed by transcranial Doppler ultrasonography. The cerebral blood flow velocity was plotted as a function of arterial carbon dioxide partial pressure. An exponential function was fitted for these plots and an exponent of curve was defined as the cerebral vascular reactivity to carbon dioxide. There was no significant change in this reactivity after cardiopulmonary bypass as compared with before bypass (before 0.028 +/- 0.003; after 0.030 +/- 0.016). For the entire series, we obtained best-fit curves of y = 2.8e0.046x (r = 0.91) and y = 3.4e0.031x (r = 0.89) (x; arterial carbon dioxide partial pressure, y; percent changes of cerebral blood flow velocity) before and after cardiopulmonary bypass. We conclude that the cerebral vascular reactivity to carbon dioxide was preserved before and after cardiopulmonary bypass in children undergoing cardiac operations. These results suggest that cerebral perfusion before and after cardiopulmonary bypass is not critically compromised.
M Kawaguchi; H Ohsumi; Y Ohnishi; T Nakajima; M Kuro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  106     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1993-12-08     Completed Date:  1993-12-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  823-7     Citation Subset:  AIM; IM    
Department of Anesthesiology, National Cardiovascular Center, Osaka, Japan.
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MeSH Terms
Blood Flow Velocity
Carbon Dioxide / blood,  pharmacology*
Cardiopulmonary Bypass*
Cerebrovascular Circulation / drug effects*
Child, Preschool
Heart Defects, Congenital / physiopathology*,  surgery
Postoperative Period
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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