| Cerebral toxoplasmosis in an allogeneic peripheral stem cell transplant recipient: case report and review of literature. | |
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MedLine Citation:
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PMID: 17428279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a patient who underwent allogeneic peripheral stem cell transplantation (PSCT) for chronic myelocytic leukemia. Twenty months after the PSCT he experienced status epilepticus. Magnetic resonance imaging (MRI) revealed a focus in the ventral thalamus-hypothalamus region. Using stereotactic biopsy with histology and specific polymerase chain reaction investigation from brain tissue, cerebral toxoplasmosis was diagnosed and treated with antiparasitic therapy. Early recognition of such serious and potentially lethal disease enabled prompt specific treatment. This case report emphasizes the role of stereotactic biopsy in diagnosis of cerebral toxoplasmosis. Other methods such as MRI are non-invasive but not sufficiently specific and sensitive. |
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Authors:
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L Cibickova; J Horacek; P Prasil; L Slovacek; A Kohout; V Cerovsky; V Hobza |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-04-11 |
Journal Detail:
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Title: Transplant infectious disease : an official journal of the Transplantation Society Volume: 9 ISSN: 1398-2273 ISO Abbreviation: Transpl Infect Dis Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-07 Completed Date: 2008-01-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883688 Medline TA: Transpl Infect Dis Country: Denmark |
Other Details:
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Languages: eng Pagination: 332-5 Citation Subset: IM |
Affiliation:
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2nd Department of Medicine, Charles University in Prague, Faculty of Medicine in Hradec Kralove and University Hospital in Hradec Kralove, Czech Republic. cibickova@seznam.cz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antiprotozoal Agents / therapeutic use Biopsy Humans Magnetic Resonance Imaging Male Middle Aged Peripheral Blood Stem Cell Transplantation / adverse effects* Polymerase Chain Reaction Stereotaxic Techniques Thalamus / radiography Toxoplasma / genetics, isolation & purification Toxoplasmosis, Cerebral / diagnosis*, drug therapy, radiography Transplantation, Homologous / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Antiprotozoal Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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