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Cerebral tissue oxygenation measured by two different probes: challenges and interpretation.
MedLine Citation:
PMID:  21809108     Owner:  NLM     Status:  Publisher    
PURPOSE: Cerebral tissue oxygenation (PbrO(2)) is most frequently monitored using a Licox CC1.SB system (LX, Integra Neuroscience, France) but recently a new probe-the Neurovent-PTO (NV)-was introduced by a different manufacturer (Raumedic, Germany). There are no prospective data on how these probes compare in clinical routine. We therefore compared both probes in comatose patients suffering from traumatic brain injury (TBI) or subarachnoid haemorrhage (SAH) during dynamic changes of inspirational oxygen fraction (FiO(2)) and mean arterial pressure (MAP). METHODS: PbrO(2) in 11 patients was recorded continuously using an LX and NV probe placed side by side into the same cerebrovascular region. Once a steady baseline value was reached FiO(2) was increased by 20% for 10 min. Once the baseline values were re-established MAP was increased by 20 mmHg for 10 min. Evaluation was performed using a four-parameter logistic function and Bland-Altman analyses. RESULTS: PbrO(2) values of both probes differed significantly at all times. The LX probe reacted significantly faster to changes in FiO(2) and MAP. Limits of agreement ranged between -32.1 and 20.0 mmHg. Mean LX values were 6.1 mmHg lower than NV values. CONCLUSIONS: Since the examined patient cohort was rather small, this study's results are preliminary. However, they suggest that LX and NV probes measure different PbrO(2) values in routine monitoring as well as during phases of dynamic changes in FiO(2) and MAP. These data therefore do not support the view that both probes can be used interchangeably.
Julius Dengler; Christin Frenzel; Peter Vajkoczy; Stefan Wolf; Peter Horn
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-2
Journal Detail:
Title:  Intensive care medicine     Volume:  -     ISSN:  1432-1238     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Neurosurgery, Charité, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany,
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