Document Detail

Cerebral tissue oxygen saturation calculated using low frequency haemoglobin oscillations measured by near infrared spectroscopy in adult ventilated patients.
MedLine Citation:
PMID:  18290334     Owner:  NLM     Status:  MEDLINE    
Oxy- (HbO2) and deoxy- (HHb) haemoglobin signals measured by near infrared (NIR) spectroscopy over the human frontal lobes frequently contain respiratory and low frequency oscillations (LFOs). It has been suggested previously that venous oxygen saturation (SvO2) can be calculated from these respiratory oscillations. In this paper, we investigated the use of a Fourier transform based algorithm to calculate an oxygen saturation measure known as S(osc)O2 which may be a close estimate of the underlying SvO2. S(osc)O2 was calculated using three different frequency ranges, (1) respiratory oscillations only, (2) LFOs only, and (3) both respiratory oscillations and LFOs. At each frequency range S(osc)O2 was calculated using either (1) the modified Beer-Lambert law (MBL) or (2) spatially resolved spectroscopy (SRS). In total six different measurements of S(osc)O2 were investigated here. Experiments were performed in six adult ventilated patients with traumatic brain injury. The patients' inspired oxygen fraction (FiO2) was raised in two hyperoxic phases. The calculated S(osc)O2 values were compared with other cerebral oxygenation measures including an intraparenchymal catheter based brain tissue oxygen tension (PbrO2) and the NIR based tissue oxygenation index (TOI). It was found that the S(osc)O2 calculated using the combined respiratory and LFO frequency range and the SRS method resulted in the highest detection rates of hyperoxic changes. This measure of S(osc)O2 may provide a viable, continuous, non invasive, bedside measure of cerebral venous oxygen saturation.
Terence S Leung; Martin M Tisdall; Ilias Tachtsidis; Martin Smith; David T Delpy; Clare E Elwell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  614     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-22     Completed Date:  2008-04-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  235-44     Citation Subset:  IM    
Department of Medical Physics and Bioengineering, University College London, London, UK.
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MeSH Terms
Cerebral Cortex / blood supply,  metabolism*
Cerebrovascular Circulation / physiology
Data Interpretation, Statistical
Fourier Analysis
Hemoglobins / metabolism*
Oximetry / methods
Oxygen / blood*
Oxygen Consumption
Partial Pressure
Respiration, Artificial*
Spectroscopy, Near-Infrared / instrumentation,  methods*
Grant Support
075608//Wellcome Trust
Reg. No./Substance:
0/Hemoglobins; 7782-44-7/Oxygen

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