Document Detail

Cerebral structure and metabolism and long-term outcome in small-for-gestational-age preterm neonates.
MedLine Citation:
PMID:  15181199     Owner:  NLM     Status:  MEDLINE    
In the present study, we compared brain development and metabolism of small-for-gestational-age (SGA) and appropriate-for-gestational-age (AGA) infants using proton magnetic resonance spectroscopy ((1)H-MRS). We tested the hypothesis that intrauterine growth retardation caused by placental insufficiency is associated with changes in cerebral metabolism and is followed by an adverse neurodevelopmental outcome at the age of 2 y. Twenty-six AGA and 14 SGA (birth weight <P 2.3) preterm infants with no major ultrasound abnormalities were enrolled prospectively. At 32 and 41 wk postmenstrual age, (1)H-MRS and magnetic resonance imaging were performed. For (1)H-MRS, a volume of interest was placed in the basal ganglia and in the periventricular white matter. Using echo times of 31 and 144 ms N-acetylaspartate/choline (NAA/Cho), lactate/Cho, myo-inositol/Cho (mI/Cho), and glutamate-glutamine-gamma-aminobutyric acid/Cho (Glx/Cho) ratios were compared between AGA and SGA groups. Griffiths' developmental quotient (DQ) values were assessed at 24 mo corrected age. Griffiths' DQ (AGA, 104 +/- 10; SGA, 99 +/- 9) and brain development assessed using magnetic resonance imaging showed no significant differences between both AGA and SGA groups, and NAA/Cho, Lac/Cho, mI/Cho, and Glx/Cho ratios were not significantly different between the groups. NAA/Cho ratios increased from 32 to 41 wk, whereas mI/Cho ratios decreased in both groups. No differences in cerebral metabolism, brain development, and DQ values between AGA and severely SGA infants could be demonstrated.
Ariadne M Roelants-van Rijn; Jeroen van der Grond; Robert H Stigter; Linda S de Vries; Floris Groenendaal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-06-04
Journal Detail:
Title:  Pediatric research     Volume:  56     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-21     Completed Date:  2005-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  285-90     Citation Subset:  IM    
Wilhelmina Children's Hospital/University Medical Center Utrecht, Department of Neonatology, Room KE 04.123.1, Lundlaan 6, 3584 EA Utrecht, The Netherlands. F.Groenendaal@WKZ.AZU.NL
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MeSH Terms
Birth Weight
Cerebral Cortex* / abnormalities,  anatomy & histology,  growth & development,  metabolism
Fetal Growth Retardation
Follow-Up Studies
Gestational Age
Infant, Low Birth Weight / metabolism*
Infant, Newborn
Infant, Premature / metabolism*
Magnetic Resonance Spectroscopy
Treatment Outcome

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