| Cerebral resuscitation: state of the art, experimental approaches and clinical perspectives. | |
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MedLine Citation:
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PMID: 16443131 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuronal injury following global cerebral ischemia continues to bea central problem of patients in the postresuscitation phase following cardiocirculatory arrest. In addition to measures focusing on rapid restoration of spontaneous circulation, the most effective treatment after cardiac arrest, as shown by large randomized trials,is the use of therapeutic mild hypothermia. Current guidelines of the International Liaison Committee on Resuscitation (ILCOR)are recommending the use of therapeutic mild hypothermia for all unconscious patients after cardiac arrest. At present there is no specific neuroprotective treatment available. Promising animal experimental data concerning the use of thrombolytic agents during cardiopulmonary resuscitation have led to a large European multicenter trial (TROICA trial) that will provide its data in 2006. |
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Authors:
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Erik Popp; Bernd W Böttiger |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neurologic clinics Volume: 24 ISSN: 0733-8619 ISO Abbreviation: Neurol Clin Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-30 Completed Date: 2006-05-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8219232 Medline TA: Neurol Clin Country: United States |
Other Details:
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Languages: eng Pagination: 73-87, vi Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, D-69120, Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis Brain / blood supply, physiopathology Brain Death / metabolism, pathology Brain Ischemia / physiopathology*, therapy* Brain-Derived Neurotrophic Factor / metabolism Cardiopulmonary Resuscitation / methods* Genes, bcl-2 / genetics Humans Hypothermia, Induced / methods Microcirculation / physiology bcl-X Protein / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor; 0/bcl-X Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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