| Cerebral perfusion mapping using a robust and efficient method for deconvolution analysis of dynamic contrast-enhanced images. | |
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MedLine Citation:
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PMID: 16682234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dynamic contrast-enhanced (DCE) imaging using MRI or CT is emerging as a promising tool for diagnostic imaging of cerebral disorders and the monitoring of tumor response to treatment. In this study, we present a robust and efficient deconvolution method based on a linearized model of the impulse residue function, which allows for the mapping of functional cerebral parameters such as cerebral blood flow, volume, mean transit time, and permeability. Monte Carlo simulation studies were performed to study the accuracy and stability of the proposed method, before applying it to clinical study cases of patients with cerebral tumors imaged using DCE CT. Functional parameter maps generated using the proposed method revealed the locations of the cerebral tumors and were found to be of sufficiently good clarity for marked regional differences in tissue vascularity and permeability to be assessed. In particular, tumor visualization and delineation were found to be better on the parameter maps that were indicative of the breakdown of the blood-brain barrier. |
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Authors:
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T S Koh; C K Markus Tan; L H Dennis Cheong; C C Tchoyoson Lim |
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Publication Detail:
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Type: Journal Article Date: 2006-05-06 |
Journal Detail:
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Title: NeuroImage Volume: 32 ISSN: 1053-8119 ISO Abbreviation: Neuroimage Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-07 Completed Date: 2006-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 643-53 Citation Subset: IM |
Affiliation:
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Center for Modeling and Control of Complex Systems, School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Ave, Singapore 639798, Singapore. etskoh@ntu.edu.sg |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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blood supply,
radiography Aged Artifacts Blood Flow Velocity / physiology Blood Volume / physiology Brain / blood supply* Brain Neoplasms / blood supply*, radiography Contrast Media / administration & dosage, pharmacokinetics Efficiency Female Frontal Lobe / blood supply*, radiography Humans Image Enhancement* Image Processing, Computer-Assisted* Iohexol / diagnostic use, pharmacokinetics Linear Models Magnetic Resonance Imaging* Male Meningeal Neoplasms / blood supply, radiography Meningioma / blood supply, radiography Microcirculation / physiopathology Middle Aged Monte Carlo Method Pituitary Neoplasms / blood supply, radiography Regional Blood Flow / physiology Reproducibility of Results Software Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 66108-95-0/Iohexol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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