Document Detail


Cerebral perfusion defects in combined cocaine and alcohol dependence.
MedLine Citation:
PMID:  12167555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cocaine abuse has been associated with widely distributed areas of significant cerebral blood flow (CBF) reductions or hypo-perfusion as well as CBF hyper-perfusion, but these perfusion abnormalities have not been examined using newer technologies such as statistical parametric mapping (SPM). These areas of abnormal CBF may be more likely among those who abuse cocaine and alcohol together. METHODS: Using SPECT with HMPAO for CBF we compared proportional scaling (PS) to histogram normalization (HEQ) in SPM among 20 controls and 32 recently abstinent cocaine abusers. We then separated the cocaine abusers into two groups (12 cocaine plus alcohol abusers and 20 cocaine alone abusers) and compared both groups to the 20 controls for brain areas of hypo- and hyper-perfusion. RESULTS: Sensitivity to hypo-perfusion was greater with HEQ than PS. Hypo-perfused areas were more likely in the 12 alcohol plus cocaine abusers than in the 20 cocaine alone abusers or 20 controls, and hyper-perfused areas were significantly more likely among the cocaine abusers than controls. The type of CBF abnormality varied by brain location with hypo-perfusion significantly more likely in occipital and temporal cortex or cerebellum and hyper-perfusion more likely in frontal and parietal cortex. CONCLUSIONS: These abnormalities in brain perfusion are consistent with previous non-SPM approaches that showed more hypo-perfusion in cocaine abusers than controls and appear to reflect vasospasm and potential compensations in cerebral blood flow.
Authors:
P C Gottschalk; Thomas R Kosten
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  68     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-08     Completed Date:  2002-11-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  95-104     Citation Subset:  IM    
Affiliation:
Departments of Veterans and Psychiatry 116A, Yale University School of Medicine, VA Connecticut Healthcare System, Psychiatry 151D, 950 Campbell Avenue, Building 35, Room 41, West Haven, CT 06516, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcoholism / complications,  physiopathology*
Brain / blood supply*,  drug effects*,  radionuclide imaging
Cerebrovascular Circulation / drug effects
Cerebrovascular Disorders / chemically induced,  diagnosis,  physiopathology*
Cocaine-Related Disorders / complications,  physiopathology*
Female
Humans
Male
Radiopharmaceuticals / diagnostic use
Sampling Studies
Technetium Tc 99m Exametazime / diagnostic use
Tomography, Emission-Computed, Single-Photon
Grant Support
ID/Acronym/Agency:
DA00167/DA/NIDA NIH HHS; DA12762/DA/NIDA NIH HHS; K05-DA0454/DA/NIDA NIH HHS; P50-DA04060/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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