| Cerebral perfusion assessment by bolus tracking using hyperpolarized 13C. | |
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MedLine Citation:
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PMID: 15004786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral perfusion was assessed with 13C MRI in a rat model after intravenous injections of the 13C-labeled compound bis-1,1-(hydroxymethyl)-1-13C-cyclopropane-D8 in aqueous solutions hyperpolarized by dynamic nuclear polarization (DNP). Since the tracer acted as a direct signal source, several of the problems associated with techniques based on traditional dynamic susceptibility contrast (DSC) MRI contrast agents were avoided. Maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) were calculated. The MTT was determined to be 2.8 +/- 0.8 sec. However, arterial partial-volume effects in the animal model prevented accurate absolute quantification of CBF and CBV. It was demonstrated that depolarization of the hyperpolarized 13C tracer via relaxation and the imaging sequence had little influence on CBF assessment when the time resolution of the imaging sequence was short compared to the MTT. However, CBV and MTT were increasingly underestimated as MTT or the depolarization rate increased if depolarization was not taken into account. With a modified bolus-tracking theory depolarization could be compensated for, assuming that the depolarization rate was known. Three separate compensation methods were investigated experimentally and by numerical simulations. |
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Authors:
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E Johansson; S Månsson; R Wirestam; J Svensson; J S Petersson; K Golman; F Ståhlberg |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 51 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-08 Completed Date: 2004-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 464-72 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiation Physics, Lund University Hospital, Lund, Sweden. edvin.johansson@radfys.lu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Blood Volume / physiology Brain / blood supply Carbon Isotopes / diagnostic use Cerebral Arteries / physiology Cerebrovascular Circulation / physiology* Computer Simulation Contrast Media Cyclopropanes / diagnostic use Image Processing, Computer-Assisted Magnetic Resonance Imaging* / methods Male Models, Animal Models, Biological Rats Rats, Wistar Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Contrast Media; 0/Cyclopropanes; 75-19-4/cyclopropane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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