| Cerebral perfusion CT: technique and clinical applications. | |
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MedLine Citation:
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PMID: 18466974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perfusion computed tomography (PCT) is an imaging technique that allows rapid, noninvasive, quantitative evaluation of cerebral perfusion by generating maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT). The concepts behind this imaging technique were developed in the 1980s', but its widespread clinical use was allowed by the recent introduction of rapid, large-coverage multidetector-row CT scanners. Key clinical applications for PCT include the diagnosis of cerebral ischemia and infarction, and evaluation of vasospasm after subarachnoid hemorrhage. PCT measurements of cerebrovascular reserve after acetazolamide challenges in patients with vascular stenoses permit evaluation of candidacy for bypass surgery and endovascular treatment. PCT has also been used to assess cerebral perfusion after head trauma and microvascular permeability in the setting of intracranial neoplasm. Some controversy exists regarding this technique, including questions regarding correct selection of an arterial input vessel, the accuracy of quantitative results, and the reproducibility of results. This article provides an overview of PCT, including details of technique, major clinical applications, and limitations. |
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Authors:
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M Wintermark; R Sincic; D Sridhar; J D Chien |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-05-07 |
Journal Detail:
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Title: Journal of neuroradiology. Journal de neuroradiologie Volume: 35 ISSN: 0150-9861 ISO Abbreviation: J Neuroradiol Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-09 Completed Date: 2009-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705086 Medline TA: J Neuroradiol Country: France |
Other Details:
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Languages: eng Pagination: 253-60 Citation Subset: IM |
Affiliation:
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Department of Radiology, Neuroradiology Section, University of California, 505, Parnassus Avenue, Box 0628, San Francisco, CA 94143-0628, USA. Max.Wintermark@radiology.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Brain Diseases / radiography* Brain Neoplasms / radiography Cerebrovascular Circulation* Craniocerebral Trauma / radiography Humans Radiographic Image Interpretation, Computer-Assisted Stroke / radiography Tomography, X-Ray Computed / methods* Vasospasm, Intracranial / radiography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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