Document Detail


Cerebral palsy in a term population: risk factors and neuroimaging findings.
MedLine Citation:
PMID:  16882824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this work was to study risk factors and neuroimaging characteristics of cerebral palsy in term and near-term infants. PATIENTS AND METHODS: Among a cohort of 334,339 infants > or = 36 weeks' gestation born at Kaiser Permanente Medical Care Program in northern California in 1991-2003, we identified infants with cerebral palsy and obtained clinical data from electronic and medical charts. Risk factors for cerebral palsy among infants with different brain abnormalities were compared using polytomous logistic regression. RESULTS: Of 377 infants with cerebral palsy (prevalence: 1.1 per 1000), 273 (72%) received a head computed tomography or MRI. Abnormalities included focal arterial infarction (22%), brain malformation (14%), and periventricular white matter abnormalities (12%). Independent risk factors for cerebral palsy were maternal age > 35, black race, and intrauterine growth restriction. Intrauterine growth restriction was more strongly associated with periventricular white matter injury than with other neuroimaging findings. Nighttime delivery was associated with cerebral palsy accompanied by generalized brain atrophy but not with cerebral palsy accompanied by other brain lesions. CONCLUSIONS: Cerebral palsy is a heterogeneous syndrome with focal arterial infarction and brain malformation representing the most common neuroimaging abnormalities in term and near-term infants. Risk factors for cerebral palsy differ depending on the type of underlying brain abnormality.
Authors:
Yvonne W Wu; Lisa A Croen; Sameer J Shah; Thomas B Newman; Daniel V Najjar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  118     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-02     Completed Date:  2006-09-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  690-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, University of California, 350 Parnassus Ave, Suite 609, San Francisco, California 94143-0137, USA. wuy@neuropeds.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Atrophy
Brain / abnormalities,  pathology,  radiography
Brain Damage, Chronic / epidemiology*,  pathology,  radiography
California / epidemiology
Cerebral Infarction / congenital,  epidemiology,  pathology,  radiography
Cerebral Palsy / epidemiology*,  pathology,  radiography
Cohort Studies
Delivery, Obstetric / statistics & numerical data
Ethnic Groups / statistics & numerical data
Female
Fetal Growth Retardation / epidemiology
Humans
Infant, Newborn
Magnetic Resonance Imaging
Maternal Age
Pregnancy
Risk
Risk Factors
Term Birth*
Time Factors
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
K02 NS46688/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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