Document Detail

Cerebral palsy and experimental hypoxia-induced perinatal brain injury: is magnesium protective?
MedLine Citation:
PMID:  11153896     Owner:  NLM     Status:  MEDLINE    
Recent retrospective, observational studies describe an association between maternal administration of magnesium and a reduction in cerebral palsy in low birthweight infants. Cerebral palsy is thought to result mainly from hypoxia-induced brain injury, and its incidence is increasing due to recent advances in obstetric and newborn intensive care. The findings of the observational studies raise the promising possibility that magnesium treatment may protect the immature brain from hypoxia-induced injury and thus decrease the incidence of cerebral palsy. Despite this promise, a critique of clinical studies indicates that a definitive answer is dependent on the outcome of prospective clinical trials. A critique of experimental animal studies indicates that a neuroprotective role for magnesium prior to, or after, immature hypoxic-ischemic brain injury is currently not supported by the available evidence. Most clinical and animal studies in this field have used magnesium sulphate as a possible therapeutic agent. Based on evidence that magnesium chloride is a preferable salt to use, the inclusion of magnesium chloride in future clinical and experimental studies is worthy of consideration.
D E Oorschot
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Magnesium research : official organ of the International Society for the Development of Research on Magnesium     Volume:  13     ISSN:  0953-1424     ISO Abbreviation:  Magnes Res     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-10     Completed Date:  2001-03-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8900948     Medline TA:  Magnes Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  265-73     Citation Subset:  IM    
Department of Anatomy and Structural Biology, University of Otago, School of Medical Sciences, Dunedin, New Zealand.
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MeSH Terms
Brain Injuries / prevention & control*
Cerebral Palsy / prevention & control*
Hypoxia-Ischemia, Brain / prevention & control*
Magnesium / pharmacology*,  therapeutic use*
Magnesium Chloride / therapeutic use
Magnesium Sulfate / therapeutic use
Obstetric Labor, Premature / therapy
Pre-Eclampsia / therapy
Reg. No./Substance:
7439-95-4/Magnesium; 7487-88-9/Magnesium Sulfate; 7786-30-3/Magnesium Chloride

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