| Cerebral pachyleptomeningitis associated with MPO-ANCA induced by PTU therapy. | |
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MedLine Citation:
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PMID: 17329921 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 34-year-old woman with hyperthyroidism, who had been previously treated with propylthiouracil (PTU) is reported. She was admitted because of clumsiness in her left hand and abnormal behavior. A neurological examination demonstrated impairment of higher cortical function, and weakness and hyperreflexia of the left leg. An MRI scan with gadolinium enhancement showed pachyleptomeningeal thickening in the right frontoparietal lobe. Blood tests revealed a high MPO-ANCA titer of 122 EU (normal:<10 EU). After steroid administration, the neurological symptoms and the MRI findings improved markedly. This is the first report of PTU-induced cerebral pachyleptomeningitis associated with a high serum MPO-ANCA titer. |
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Authors:
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Takato Abe; Shigeru Nogawa; Norio Tanahashi; Junichi Shiraishi; Eiji Ikeda; Norihiro Suzuki |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-03-01 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 46 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-03-01 Completed Date: 2007-04-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 247-50 Citation Subset: IM |
Affiliation:
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Neurology, Keio University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Antineutrophil Cytoplasmic / blood* Antithyroid Agents / adverse effects*, therapeutic use Arachnoid* / pathology Dexamethasone / therapeutic use Female Glucocorticoids / therapeutic use Graves Disease / drug therapy Humans Magnetic Resonance Imaging Meningitis / blood, chemically induced*, diagnosis, drug therapy Peroxidase / blood* Pia Mater* / pathology Prednisolone / therapeutic use Propylthiouracil / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antineutrophil Cytoplasmic; 0/Antithyroid Agents; 0/Glucocorticoids; 50-02-2/Dexamethasone; 50-24-8/Prednisolone; 51-52-5/Propylthiouracil; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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