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Cerebral oxygenation following epinephrine infusion.
MedLine Citation:
PMID:  22853845     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Evidence suggests that the autonomic nervous system may actively regulate the cerebral vasculature. In this study, central hemodynamics and brain oxy-hemoglobin, deoxy-hemoglobin and total hemoglobin changes (bO(2)Hb, bdHb and bTHb) were monitored during infusion of epinephrine (0.06μg/kg/min over 6min, and 0.12μg/kg/min for 3min) in 12 men. Epinephrine decreased mean arterial pressure (MAP) and total peripheral resistance (TPR), while heart rate (HR), stroke volume (SV) and cardiac output (CO) increased, but did not affect bO(2)Hb, bdHb or bTHb. However, upon the cessation of epinephrine infusion an increase in both Oxy- and Total Hb occurred which peaked at 3min post infusion (+6.0±4.6 and +4.9±4.8μmol/L respectively, P<0.05) and persisted for 20min post infusion (+1.5±2.2 and +1.8±2.7μmol/L respectively, P<0.05). No evidence was found for reduction in cerebral oxygenation during a cold-pressor test. The results of the present study demonstrated that clinical doses of epinephrine result in a delayed increase in cortical blood volume due to an increase in Oxy-Hb, consistent with vasodilation.
Authors:
Craig D Steinback; Petra Zubin; Toni Breskovic; Darija Bakovic; Nediljko Pivac; Zeljko Dujic
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-30
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  -     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada.
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