Document Detail

Cerebral ocular Whipple's disease: a 62-year odyssey from death to diagnosis.
MedLine Citation:
PMID:  7536902     Owner:  NLM     Status:  MEDLINE    
A 47-year-old white man with dementia, supranuclear ophthalmoplegia, and myoclonic ocular and facial jerks died in 1931. The case report in 1936 by Ford and Walsh diagnosed encephalitis. In 1993, we made a clinical diagnosis of Whipple's disease on the basis of the 1936 publication. We restudied the pathologic material and found, in addition to extensive encephalitis, PAS-positive material in only the eye, brain, spinal cord, and pituitary. Electron microscopy demonstrated free and intracytoplasmic microorganisms in the eye and brain. We review the history of cerebral ocular Whipple's disease and the implications from this case, which occurred before the development of antibiotics.
D L Knox; W R Green; J C Troncoso; J H Yardley; J Hsu; D S Zee
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Neurology     Volume:  45     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-23     Completed Date:  1995-05-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  617-25     Citation Subset:  AIM; IM    
Wilmer Ophthalmological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
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MeSH Terms
Astrocytes / pathology
Brain / pathology
Brain Diseases, Metabolic / pathology*
Eye / pathology
Eye Diseases / pathology*
Macrophages / pathology
Middle Aged
Whipple Disease / pathology*

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