Document Detail

Cerebral nocardiosis--clinical and pathological findings in three patients.
MedLine Citation:
PMID:  2686611     Owner:  NLM     Status:  MEDLINE    
Cerebral nocardiosis is an uncommon but increasingly diagnosed infection in Australia. We report three cases. One occurred in an immunosuppressed male in whom the diagnosis was made at autopsy, one in an otherwise healthy elderly woman with subcutaneous nocardiosis, and the third was a posterior fossa nocardial abscess without systemic involvement occurring in a previously healthy woman after surgical excision of a meningioma. Primary cerebral nocardiosis is rare, with only two cases of primary posterior fossa nocardiosis reported. The cases highlight the difficulty of diagnosis and the need for aggressive treatment with a combined approach of surgical drainage and antibiotic therapy. The antibiotic regime of choice is the subject of controversy. Rifampicin, cephalosporins, imipenem, sulphonamides and other agents were used with varying success in our patients. Cerebral nocardiosis should be considered in any patient with a cerebral space occupying lesion.
G K Herkes; J Fryer; R Rushworth; R Pritchard; R M Wilson; R Joffe
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Australian and New Zealand journal of medicine     Volume:  19     ISSN:  0004-8291     ISO Abbreviation:  Aust N Z J Med     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-01-11     Completed Date:  1990-01-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1264322     Medline TA:  Aust N Z J Med     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  475-8     Citation Subset:  IM    
Royal North Shore Hospital, St. Leonards, NSW.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Brain Abscess / drug therapy,  microbiology,  pathology*
Middle Aged
Nocardia Infections / drug therapy,  microbiology,  pathology*
Nocardia asteroides / isolation & purification
Reg. No./Substance:
0/Anti-Bacterial Agents

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