| Cerebral microhemorrhage. | |
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MedLine Citation:
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PMID: 16397165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: With the advent of modern MRI imaging techniques, cerebral microhemorrhages have been increasingly recognized on gradient-echo (GE) or T2*-weighted MRI sequences in different populations. However, in clinical practice, their diagnostic value, associated risk, and prognostic significance are often unclear. This review summarizes the pathophysiology, differential diagnosis, epidemiology, and clinical significance of cerebral microhemorrhages. SUMMARY OF REVIEW: Focal areas of signal loss on GE MRI imaging pathologically represent focal hemosiderin deposition associated with previous hemorrhagic events. Cerebral microhemorrhages have been noted in healthy elderly, ischemic cerebrovascular disease, intracerebral hemorrhage (ICH), cerebral amyloid angiopathy (CAA), and in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Microhemorrhages have been associated with older age, hypertension, smoking, white matter disease, lacunar infarcts, previous ischemic stroke, or ICH. In CAA, microhemorrhages predict both the risk of recurrent lobar ICH and future clinical decline. In patients with ischemic cerebrovascular disease, microhemorrhage number and location may be associated with executive dysfunction and may predict the occurrence of ICH and lacunar infarction. CONCLUSIONS: When cerebral microhemorrhages are diagnosed on MRI, conclusions regarding their significance and associated risks should be made based on the population examined. Further studies to characterize the associated risks of cerebral microhemorrhages in different stroke populations are needed to use this new imaging marker in therapeutic decisions. |
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Authors:
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Anand Viswanathan; Hugues Chabriat |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-01-05 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 37 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-24 Completed Date: 2006-03-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 550-5 Citation Subset: IM |
Affiliation:
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Department of Neurology, CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged CADASIL / complications, diagnosis Cerebral Amyloid Angiopathy / complications, diagnosis Female Humans Intracranial Hemorrhages / diagnosis*, pathology* Magnetic Resonance Imaging / methods* Male Middle Aged Prognosis Risk Risk Factors Stroke / complications, diagnosis Time Factors Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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