| Cerebral microbleeds predict first-ever symptomatic cerebrovascular events. | |
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MedLine Citation:
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PMID: 19765890 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Cerebral microbleeds (CMB) on gradient-echo T2*-weighted magnetic resonance image (MRI) are frequently seen in patients with cerebral diseases. In this observational study we assessed whether CMB are a predictive factor for first-ever cerebrovascular events. PATIENTS AND METHODS: This study consisted of 698 subjects without a history of symptomatic cerebrovascular events, who received gradient-echo T2*-weighted MRI for 3 months between November 2003 and January 2004 in Kishiwada City Hospital, Osaka, Japan. These subjects were then observed as outpatients for over 3.5 years. RESULTS: The prevalence of CMB at baseline was 17.0% (119/698) in this population, and the follow-up rate was 51%. A total of 36 first-ever symptomatic cerebrovascular events were observed during the 3 and a half-year follow-up period. First-ever symptomatic cerebrovascular events occurred significantly more frequently in subjects with CMB (15 cases) than those without CMB (21 cases) (p=0.001). Even after adjusting for age, sex and hypertension, it was revealed that the presence of CMB was an independent predictor for the first-ever symptomatic cerebrovascular event by using the Cox proportional hazards model (hazard ratio, 2.87; 95% CI, 1.27-6.48; p=0.01). CONCLUSION: The presence of CMB is an independent predictor of first-ever symptomatic cerebrovascular diseases. |
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Authors:
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Tomofumi Nishikawa; Tetsuya Ueba; Motohiro Kajiwara; Ichro Fujisawa; Naomi Miyamatsu; Kohsuke Yamashita |
Publication Detail:
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Type: Journal Article Date: 2009-09-17 |
Journal Detail:
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Title: Clinical neurology and neurosurgery Volume: 111 ISSN: 1872-6968 ISO Abbreviation: Clin Neurol Neurosurg Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-06 Completed Date: 2010-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502039 Medline TA: Clin Neurol Neurosurg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 825-8 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Kishiwada City Hospital, 1001 Gakuhara-cho, Kishiwada, Osaka 596-8501, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aging / physiology Cerebral Hemorrhage / epidemiology*, pathology Cerebral Infarction / epidemiology, pathology Cerebrovascular Disorders / epidemiology*, pathology Female Follow-Up Studies Forecasting Humans Kaplan-Meiers Estimate Magnetic Resonance Imaging Male Middle Aged Prognosis Proportional Hazards Models Prospective Studies Software Stroke / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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