| Cerebral microbleeds in patients with intracerebral hemorrhage are associated with previous cerebrovascular diseases and white matter hyperintensity, but not with regular use of antiplatelet agents. | |
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MedLine Citation:
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PMID: 19706998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The validity of regular use of antiplatelet agents was retrospectively assessed in 106 patients with intracerebral hemorrhage (ICH) (supratentorial hemorrhage 92, lobar 22 and deep 70; and infratentorial hemorrhage 14) who underwent T(2)*-weighted gradient-echo magnetic resonance (MR) imaging between January 2005 and December 2006 in Kishiwada City Hospital. The prevalence of cerebral microbleeds was 54.7% (58/106), and the presence was significantly associated with higher age (odds ratio 3.09, p = 0.007), presence of white matter hyperintensity on T(2)-weighted MR imaging (odds ratio 2.36, p = 0.032), and previous ICH and/or cerebral infarction (odds ratio 4.77, p = 0.020). Previous ICH and/or cerebral infarction was independently associated with the presence of cerebral microbleeds after adjustment for age, white matter hyperintensity, and hypertension (odds ratio 4.07, p = 0.043). Regular use of antiplatelet agents was not associated with the presence of cerebral microbleeds, whether the patients had cerebrovascular diseases or not. Our findings suggest that antiplatelet medication can be justified for patients with cerebral microbleeds. |
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Authors:
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Tomofumi Nishikawa; Tetsuya Ueba; Motohiro Kajiwara; Naomi Miyamatsu; Kohsuke Yamashita |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurologia medico-chirurgica Volume: 49 ISSN: 1349-8029 ISO Abbreviation: Neurol. Med. Chir. (Tokyo) Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-26 Completed Date: 2009-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0400775 Medline TA: Neurol Med Chir (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 333-8; discussion 338-9 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Kishiwada City Hospital, Kishiwada, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Brain / blood supply, pathology*, physiopathology Cerebral Hemorrhage / chemically induced*, epidemiology* Cerebral Infarction / epidemiology Cerebrovascular Disorders / epidemiology* Comorbidity Female Humans Magnetic Resonance Imaging Male Microcirculation / physiology Middle Aged Nerve Fibers, Myelinated / pathology* Platelet Aggregation Inhibitors / adverse effects* Prevalence Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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