| Cerebral metastasis and other cerebral events in women with ovarian cancer. | |
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MedLine Citation:
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PMID: 12384107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine the incidence, imaging findings and prognostic significance of cerebral metastases and other cerebral events in women with ovarian cancer. METHOD: A 5-year retrospective review of all women with ovarian cancer who had cranial imaging was undertaken at two major gynaecological oncology centers. RESULTS: Of 1222 women under clinical review, 78 underwent cranial imaging and 13 (1.1%) had cerebral metastasis. Computed tomography (CT) was diagnostic of parenchymal disease in 12 and magnetic resonance imaging (MRI) showed leptomeningeal disease in two. The women were aged between 23 and 73 years and all had stage III or IV disease at presentation. Cerebral metastasis occurred at 6-60 months from initial diagnosis, with death occurring predominantly within 12 months, but with five survivors at 4-45 months. Of the remaining 65 women, 10 had cerebrovascular disease and three had unrelated lesions. CONCLUSION: Cerebral metastasis remains a rare event in women with ovarian cancer but may be an isolated late event associated with survival beyond a year after neurosurgery and chemotherapy. CT should be the first investigation as the incidence of cerebrovascular disease is similar to that of metastatic disease. |
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Authors:
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A Sanderson; S C Bonington; B M Carrington; D L Alison; J A Spencer |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Clinical radiology Volume: 57 ISSN: 0009-9260 ISO Abbreviation: Clin Radiol Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-10-17 Completed Date: 2002-11-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1306016 Medline TA: Clin Radiol Country: England |
Other Details:
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Languages: eng Pagination: 815-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Radiology and Medical Oncology, St James's University Hospital, Leeds, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain Neoplasms / diagnosis, epidemiology, secondary* England / epidemiology Female Follow-Up Studies Humans Incidence Magnetic Resonance Imaging Middle Aged Neoplasm Staging Ovarian Neoplasms* Prognosis Retrospective Studies Survival Rate Tomography, X-Ray Computed Treatment Outcome |
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