Document Detail


Cerebral metabolites in patients with acute and subacute strokes: concentrations determined by quantitative proton MR spectroscopy.
MedLine Citation:
PMID:  7645484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to determine the feasibility of measuring concentrations of cerebral metabolites in acute and subacute stroke patients using single-voxel localized proton MR spectroscopy and to compare these concentrations to those in contralateral brain regions and in normal healthy volunteers. SUBJECTS AND METHODS: Single-voxel proton MR spectroscopy and MR imaging were performed in 14 stroke patients, at times ranging from 2 hr to 10 days following the onset of symptoms. Signals from choline, creatine, N-acetyl-L-aspartate (NAA), and lactate were quantified in the infarcted region (n = 14) and in the hemisphere contralateral to the stroke (n = 8) and compared with data obtained from a group of 10 control subjects. RESULTS: Infarcts were characterized by significantly increased lactate (12 of 14 patients; 7.5 +/- 8.9 mumol/g wet weight, mean +/- SD) and significantly decreased NAA (12 of 14 patients; 5.5 +/- 3.2 mumol/g wet weight), compared with contralateral brain regions and control data in healthy volunteers. Significant reductions in choline, creatine, and NAA were also found in contralateral brain regions compared with the control patients. CONCLUSION: Quantitative single-voxel proton spectroscopy is feasible for use in clinical studies of acute stroke. Ratio measurements or comparison with contralateral metabolites may be misleading because all metabolites may change during infarction, and contralateral metabolite levels may also be different from normal subjects.
Authors:
V P Mathews; P B Barker; S J Blackband; J C Chatham; R N Bryan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  165     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-09-18     Completed Date:  1995-09-18     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  633-8     Citation Subset:  AIM; IM    
Affiliation:
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
Aspartic Acid / analogs & derivatives*,  analysis
Brain / metabolism*
Cerebrovascular Disorders / metabolism*
Child
Choline / analysis*
Creatine / analysis*
Feasibility Studies
Female
Humans
Lactates / analysis*
Lactic Acid
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate

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