| Cerebral metabolite dynamics during temporary complete ischemia in rats monitored by time-shared 1H and 31P NMR spectroscopy. | |
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MedLine Citation:
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PMID: 2319935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The changes in cerebral phosphorus metabolites, intracellular pH, and lactate during 30 min of complete global ischemia and 2 h of reperfusion were monitored by time-shared 1H and 31P in vivo NMR spectroscopy in rats. After the induction of ischemia, intracellular pH decreased from 7.14 +/- 0.01 to 6.32 +/- 0.10, and lactate concentration increased from 1.6 +/- 0.4 to 15.8 +/- 2.5 mumol/g; ATP and phosphocreatine were totally depleted, while inorganic phosphate increased 715 +/- 47%. Within 1 h after blood flow was restored, high-energy phosphates and lactate levels had recovered close to baseline levels. The changes in intracellular pH and lactate levels during ischemia and reperfusion correlated well. |
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Authors:
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L H Chang; R Shirane; P R Weinstein; T L James |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 13 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-05-10 Completed Date: 1990-05-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 6-13 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry, School of Medicine, University of California, San Francisco 94143. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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analysis Animals Brain / metabolism* Brain Chemistry Brain Ischemia / metabolism* Hydrogen Hydrogen-Ion Concentration Lactates / analysis Magnetic Resonance Spectroscopy* Phosphocreatine / analysis Phosphorus Rats Rats, Inbred Strains Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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NS 22022-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 1333-74-0/Hydrogen; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 7723-14-0/Phosphorus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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