| Cerebral metabolism of patients with stenosis of the internal carotid artery before and after endarterectomy. | |
| | |
MedLine Citation:
|
PMID: 8594065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Occlusion or severe stenosis, with a reduction in the diameter of more than 70% of the extracranial arteries may lead to hpoperfusion of the brain with an increased risk of cerebral infarction. The aim of this study was to investigate whether endarterectomy of stenosed internal carotid arteries leads to alternations in cerebral metabolism in regions in which no infarcts were visible with magnetic resonance imaging (MRI). We studied 10 healthy control subjects and 20 patients with transient or nondisabling cerebral ischemia with MRI and 1H magnetic resonance spectroscopic imaging. All patients underwent carotid endarterectomy. Patients were examined 1 week before and 3-6 months after carotid endarterectomy. The N-acetyl aspartate (NAA)/choline ratio in the symptomatic hemisphere before endarterectomy (2.29 +/- 0.42) was significantly (p < 0.001) lower than for control subjects (3.18 +/- 0.32). In five of the patients lactate was detected preoperatively in regions that were not infarcted. The NAA/choline ratio in the symptomatic hemisphere of these five patients did not increase significantly after endarterectomy (1.99 +/- 0.22 vs. 2.23 +/- 0.48). The NAA/choline ratio in patients without lactate preoperatively increased significantly (p < 0.01) after endarterectomy to a normal level (from 2.39 +/- 0.42 to 2.92 +/- 0.52). These results indicate that the presence of cerebral lactate may predict whether the NAA/choline ratio increases after carotid endarterectomy. |
| | |
Authors:
|
J van der Grond; R Balm; C J Klijn; L J Kapelle; B C Eikelboom; W P Mali |
Related Documents
:
|
11102635 - Definition of the anterior choroidal artery territory in rats using intraluminal occlud... 3515635 - Hemorrhagic cerebral infarction--a prospective study. 17895815 - Bilateral isolated lateral geniculate body lesions in a patient with pancreatitis and m... 16955035 - Endoscopic third ventriculostomy for occlusive hydrocephalus caused by cerebellar infar... 16845845 - Newer cardiac imaging techniques: multidetector ct angiography. 1921435 - Effects of acute right ventricular ischemia on ventricular interactions during prosthet... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 16 ISSN: 0271-678X ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 1996 Mar |
Date Detail:
|
Created Date: 1996-04-10 Completed Date: 1996-04-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 320-6 Citation Subset: IM |
Affiliation:
|
Department of Radiology, University Hospital Utrecht, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aspartic Acid / analogs & derivatives, metabolism Brain / metabolism* Carotid Artery, Internal* Carotid Stenosis / metabolism*, surgery Choline / metabolism Endarterectomy* Female Humans Lactates / metabolism Lactic Acid Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
0/Lactates; 50-21-5/Lactic Acid; 56-84-8/Aspartic Acid; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Noninvasive quantification of rCBF using positron emission tomography.
Next Document: Increased blood-brain permeability with hyperosmolar mannitol increases cerebral O2 consumption and ...