| Cerebral metabolism is influenced by muscle ischaemia during exercise in humans. | |
| | |
MedLine Citation:
|
PMID: 12621535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Maximal exercise reduces the cerebral metabolic ratio (O2/(glucose + 1/2 lactate)) to < 4 from a resting value close to 6, and only part of this decrease is explained by the 'intent' to exercise. This study evaluated whether sensory stimulation of brain by muscle ischaemia would reduce the cerebral metabolic ratio. In 10 healthy human subjects the cerebral arterial-venous differences (a-v differences) for O2, glucose and lactate were assessed before, during and after three bouts of 10 min cycling with equal workload: (1) control exercise at light intensity, (2) exercise that elicited a high rating of perceived exertion due to a 100 mmHg thigh cuff, and (3) exercise followed by 5 min of post-exercise muscle ischaemia that increased blood pressure by approximately 20 %. Control exercise did not significantly affect the a-v differences. However, during the recovery from exercise with thigh cuffs the cerebral metabolic ratio decreased from a resting value of 5.4 +/- 0.2 to 4.0 +/- 0.4 (mean +/- S.E.M.; P < 0.05) as a discrete lactate efflux from the brain at rest shifted to a slight uptake. Also, following post-exercise muscle ischaemia, the cerebral metabolic ratio decreased to 4.5 +/- 0.3 (P < 0.05). The results support the hypothesis that during exercise, cerebral metabolism is influenced both by the mental effort to exercise and by sensory input from skeletal muscles. |
| | |
Authors:
|
Mads K Dalsgaard; Lars Nybo; Yan Cai; Niels H Secher |
Related Documents
:
|
8775645 - Blood lactate and ammonia in short-term anaerobic work following induced alkalosis. 9789795 - Relationship between emg blood lactate, and plasma catecholamine thresholds during grad... 6401405 - Endurance training affects lactate clearance, not lactate production. 23154055 - Resistance training improves cardiac output, exercise capacity and tolerance to positiv... 3421175 - Effect of catheter ablation of the atrioventricular junction on quality of life and exe... 23260705 - Left ventricular distensibility does not explain impaired exercise capacity in pediatri... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Experimental physiology Volume: 88 ISSN: 0958-0670 ISO Abbreviation: Exp. Physiol. Publication Date: 2003 Mar |
Date Detail:
|
Created Date: 2003-03-06 Completed Date: 2003-10-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: England |
Other Details:
|
Languages: eng Pagination: 297-302 Citation Subset: IM |
Affiliation:
|
Department of Anaesthesia and The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark. madskd@tiscali.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Glucose / metabolism Brain / metabolism* Exercise / physiology* Female Humans Ischemia / metabolism* Lactic Acid / blood Male Muscle, Skeletal / blood supply* Oxygen / blood Rest |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 50-21-5/Lactic Acid; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Static fusimotor action during locomotion in the decerebrated cat revealed by cross-correlation of s...
Next Document: Ageing of ex-sportsmen: ergonometric parameters of ex-elite athletes.