Document Detail


Cerebral metabolism in sheep: a comparative study of the adult, the lamb, and the fetus.
MedLine Citation:
PMID:  1147049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cerebral uptakes of glucose, oxygen, lactate, pyruvate, acetoacetate and beta-hydroxybutyrate were compared in the adult, the fetal, and the newborn sheep. Beginning 1-2 days after surgery, we withdrew samples simultaneously from an artery and from the sagittal sinus for up to 2 wk. At all ages glucose was the only substrate taken up in significant quantity relative to oxygen. The glucose-oxygen quotients were 0.98 less than 1.03 less than 1.08 in adults; 0.92 less than 0.99 less than 1.06 in lambs; 0.92 less than 0.98 less than 1.03 in fetuses. These quotients were not significantly different. There was a significant (P less than .05) arteriovenous difference for lactate in the adult (-0.031 mM), but not in the lamb or fetus. A significant (P less than .05) arteriovenous difference pyruvate was found in the adult (-0.013 mM) and in the fetus (-0.020 mM). The findings of a glucose-oxygen quotient of approximately 1 and the lack of significant lactate production in fetal sheep brain are consistent with the hypothesis that anerobic glycolysis is unimportant to the steady-state cerebral metabolism of the fetal sheep.
Authors:
M D Jones; L I Burd; E L Makowski; G Meschia; F C Battaglia
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  229     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-10-11     Completed Date:  1975-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetoacetates / blood,  metabolism
Aging*
Animals
Animals, Newborn / metabolism*
Blood Gas Analysis
Blood Glucose
Brain / embryology,  metabolism*
Glucose / metabolism
Glycolysis
Hydroxybutyrates / blood,  metabolism
Lactates / blood,  metabolism
Oxygen Consumption
Pyruvates / blood
Sheep / metabolism*
Chemical
Reg. No./Substance:
0/Acetoacetates; 0/Blood Glucose; 0/Hydroxybutyrates; 0/Lactates; 0/Pyruvates; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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