Document Detail

Cerebral metabolic rate for glucose during the first six months of life: an FDG positron emission tomography study.
MedLine Citation:
PMID:  8777676     Owner:  NLM     Status:  MEDLINE    
AIM: To measure the local cerebral metabolic rate for glucose (LCMRGlc) in neonatal brains during maturation using positron emission tomography (PET) and 2-[18F]fluoro-2-deoxy-D-glucose (FDG). METHODS: Twenty infants were studied using PET during the neonatal period. The postconceptional age ranged from 32.7 to 60.3 weeks. All infants had normal neurodevelopment and were normoglycaemic. The development of the infants was carefully evaluated (follow up 12-36 months) clinically, and by using a method based on Gesell Amatruda's developmental diagnosis. LCMRGlc was quantitated using PET derived from FDG kinetics and calculated in the whole brain and for regional brain structures. RESULTS: LCMRGlc for various cortical brain regions and the basal ganglia was low at birth (from 4 to 16 mumol/100 g/minute). In infants 2 months of age and younger LCMRGlc was highest in the sensorimotor cortex, thalamus, and brain stem. By 5 months, LCMRGlc had increased in the frontal, parietal, temporal, occipital and cerebellar cortical regions. In general, the whole brain LCMRGlc correlated with postconceptional age (r = 0.90; P < 0.001). The change in the glucose metabolic pattern observed in the neonatal brain reflects the functional maturation of these brain regions. CONCLUSION: These findings show that LCMRGlc in infants increases with maturation. Accordingly, when LCMRGlc is measured during infancy, the postconceptional age has to be taken into account when interpretating the results.
A Kinnala; H Suhonen-Polvi; T Aärimaa; P Kero; H Korvenranta; U Ruotsalainen; J Bergman; M Haaparanta; O Solin; P Nuutila; U Wegelius
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  74     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-09-13     Completed Date:  1996-09-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F153-7     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Turku, Finland.
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MeSH Terms
Age Factors
Brain / metabolism*,  radionuclide imaging
Brain Stem / metabolism
Cerebellar Cortex / metabolism
Cerebellum / metabolism
Cerebral Cortex / metabolism
Child, Preschool
Deoxyglucose / analogs & derivatives,  diagnostic use
Fluorine Radioisotopes / diagnostic use
Fluorodeoxyglucose F18
Follow-Up Studies
Glucose / metabolism*
Infant, Newborn
Infant, Premature
Retrospective Studies
Thalamus / metabolism
Tomography, Emission-Computed
Reg. No./Substance:
0/Fluorine Radioisotopes; 154-17-6/Deoxyglucose; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

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