Document Detail

Cerebral metabolic rate for glucose after neonatal hypoglycaemia.
MedLine Citation:
PMID:  9179539     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We studied the effect of neonatal hypoglycaemia on the local cerebral metabolic rate for glucose (LCMRglc). MATERIALS AND METHODS: Eight newborn infants with neonatal hypoglycaemia were studied. The LCMRglc in the whole brain, in five cerebral regions and in skeletal muscles were quantitated using positron emission tomography (PET) and 2-[18F]Fluoro-2-deoxy-D-glucose (FDG). The PET studies were performed at the age of 5.3 +/- 6.2 days during normoglycaemia. The LCMRglc of these infants were compared to the age-adjusted LCMRglc of eight infants with suspected hypoxic-ischaemic brain injury but with normal neurological development. RESULTS: After neonatal hypoglycaemia the age-adjusted LCMRglc in the whole brain was not lower than LCMRglc of the control infants (5.33 +/- 0.60 mumol/100 g/min vs. 6.71 +/- 0.60 mumol/100 g/min). Also the metabolic rate for glucose (MRglc) in the skeletal muscles was similar in hypoglycaemic and control infants (5.56 +/- 2.48 mumol/100 g/min vs. 6.99 +/- 2.41 mumol/100 g/min). CONCLUSION: MRglc in brain and in skeletal muscle seems to be normal after neonatal hypoglycaemia, although larger group of patients with more severe hypoglycaemia are needed to confirm this finding.
A Kinnala; P Nuutila; U Ruotsalainen; M Teräs; J Bergman; M Haaparanta; O Solin; H Korvenranta; T Aärimaa; U Wegelius; P Kero; H Suhonen-Polvi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Early human development     Volume:  49     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-07-22     Completed Date:  1997-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  63-72     Citation Subset:  IM    
Department of Pediatrics, University of Turku, Finland.
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MeSH Terms
Brain / metabolism*
Glucose / metabolism*
Hypoglycemia / congenital,  metabolism*,  physiopathology
Infant, Newborn
Muscle, Skeletal / metabolism*
Pregnancy Complications
Tomography, Emission-Computed
Reg. No./Substance:

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