Document Detail

Cerebral metabolic alterations and cognitive dysfunction in chronic kidney disease.
MedLine Citation:
PMID:  21216887     Owner:  NLM     Status:  Publisher    
BACKGROUND: The diagnosis of uraemic encephalopathy is considered if patients with end-stage renal disease present with neuropsychiatric symptoms. However, cognitive deficits may occur in patients with chronic kidney disease (CKD) long before any overt neurological symptoms can be observed. We hypothesized that cognitive dysfunction in patients with CKD both, treated and untreated by haemodialysis, may correspond to metabolic changes in distinct brain regions. METHODS: We performed magnetic resonance spectroscopy (MRS) ((1)H-MRS) of the brain in 23 non-dialysed patients with CKD (Stages 4-5) and in 15 haemodialysed patients. Healthy controls (n = 63) adjusted for age and education were recruited from the social environment of the patients' population. Attention, learning and memory were assessed by psychometric testing. RESULTS: MRS alterations were predominantly found in the white matter. Concentrations of creatine-containing compounds (Cr) were decreased in dialysed and non-dialysed patients. Choline concentration (Cho) and combined N-acetylaspartate and N-acetylaspartylglutamate concentration (NAx) were reduced only in dialysed patients. Disturbance in memory and learning ability as well as attention deficits were observed in both patient groups. Of note, attention deficits were more severe in dialysed patients. MRS results correlated with attention deficits in dialysed patients. CONCLUSIONS: CKD patients without clinical signs of uraemic encephalopathy showed metabolic disturbances in distinct brain regions as well as cognitive impairments. Haemodialysis was accompanied with more severe cognitive dysfunction and metabolic alternations than CKD alone. Although the small sample size limits the interpretation of the data, a negative impact of haemodialysis on cognitive function must be considered.
Anita Blanka Tryc; Güldan Alwan; Martin Bokemeyer; Annemarie Goldbecker; Hartmut Hecker; Marion Haubitz; Karin Weissenborn
Related Documents :
10792417 - Autonomic cardiovascular regulation in patients with obstructive sleep apnoea: a study ...
18678567 - Influence of spontaneous pursed lips breathing on walking endurance and oxygen saturati...
20298367 - The extent of emphysema in patients with copd.
3936867 - Effect of mucolytic and bronchodilator aerosol therapy on airway resistance in mechanic...
23396807 - Should guidelines for conventional hemodialysis initiation in acute methanol poisoning,...
3457897 - A study of histocompatibility antigens in patients with motor neuron disease in the nor...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-7
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  -     ISSN:  1460-2385     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Clinic for Neurology, Hannover Medical School, Hannover, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of leptin on polymorphonuclear leucocyte functions in healthy subjects and haemodialysis pati...
Next Document:  Success in physician prehospital rapid sequence intubation: what is the effect of base speciality an...