| Cerebral magnetic resonance imaging in patients with or without antiphospholipid antibodies. | |
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MedLine Citation:
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PMID: 9541097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine in patients with systemic lupus erythematosus (SLE) or with primary antiphospholipid syndrome (PAPS) the prevalence of cerebral magnetic resonance imaging changes (MRI) and the relationship with antiphospholipid antibodies. METHODS: Twenty-nine consecutive SLE patients, 24 PAPS patients and 31 healthy controls were prospectively included in the study and underwent MRI Scan over a 1-year period. MRI scans were analyzed separately by a neuroradiologist for white matter changes [periventricular hyperintensity (PVH) (0-6 scale), deep white matter hyperintensity (WMH) (0-24 scale)], and one neurologist for cerebral atrophy (0-39 scale) and stroke subtypes. Statistical assessment consisted of a discriminant analysis performed with SAS-package with MRI data as dependent variables and, as independent variables, age, sex, arterial hypertension, diabetes mellitus, cardiopathy, migraine, neurological symptoms, antiphospholipid antibodies, SLE, steroid treatment. RESULTS: The prevalence of cerebral atrophy was increased in both SLE and PAPS groups relative to controls. PVH and WMH scores were significantly higher in SLE and PAPS than in controls. Focal infarct did not differ in the SLE group when compared with PAPS. PVH and WMH scores were significantly higher in patients with neurological symptoms. Using a correlation test we found a weak significant correlation between cerebral atrophy and lupus anticoagulant. The multivariate analysis found only three independent variables related to PVH and WMH: age, the diagnosis of SLE and cerebral atrophy. CONCLUSIONS: Age, presence of SLE and presence of neurological symptoms were independently related with WMH and PVH, but not antiphospholipid antibodies. |
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Authors:
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E Hachulla; U Michon-Pasturel; D Leys; J P Pruvo; V Queyrel; E Masy; J Arvieux; C Caron; F Brevet-Coupé; P Y Hatron; B Devulder |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lupus Volume: 7 ISSN: 0961-2033 ISO Abbreviation: Lupus Publication Date: 1998 |
Date Detail:
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Created Date: 1998-05-21 Completed Date: 1998-05-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9204265 Medline TA: Lupus Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 124-31 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Lille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antibodies, Anticardiolipin / analysis Antibodies, Antiphospholipid / immunology* Antiphospholipid Syndrome / diagnosis, immunology Atrophy Autoantibodies / analysis, immunology Brain / immunology, pathology*, physiopathology Cerebral Infarction / pathology Female Glycoproteins / immunology Humans Immunoglobulin G / analysis, immunology Immunoglobulin M / analysis, immunology Logistic Models Lupus Coagulation Inhibitor / analysis Lupus Erythematosus, Systemic / diagnosis, immunology Magnetic Resonance Imaging* Male Middle Aged Multivariate Analysis Risk Factors Severity of Illness Index Thrombosis / diagnosis beta 2-Glycoprotein I |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anticardiolipin; 0/Antibodies, Antiphospholipid; 0/Autoantibodies; 0/Glycoproteins; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Lupus Coagulation Inhibitor; 0/beta 2-Glycoprotein I |
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