Document Detail

Cerebral lupus in patients whilst on treatment for lupus nephritis with cyclosporine.
MedLine Citation:
PMID:  12464536     Owner:  NLM     Status:  MEDLINE    
Two young female patients who were treated for severe lupus nephritis with cyclosporine, developed, while the renal parameters remained stable, signs of cerebral lupus (bilateral papiloedema and cranial nerve palsy in one patient and grand mal seizures in the second). The first patient responded to plasmapheresis and i.v. cyclophosphamide, and the second to temporary increase in prednisone with anti-convulsant medication. Both case histories suggest that cyclosporine, whilst controlling lupus nephritis, was not able to prevent serious attacks of cerebral lupus. This discrepancy might be related to relative inability of the drug to reduce antibody production or to the existence of heterogeneous pathogenetic mechanisms of lupus in different organ systems.
M Hussein; J Mooij; H Roujouleh
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  10     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-04     Completed Date:  2003-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  104-6     Citation Subset:  IM    
Department of Nephrology, Al Hada Armed Forces Hospital, P.O. Box 1347, Taif, Saudi Arabia.
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MeSH Terms
Abducens Nerve Diseases / etiology*
Cyclosporine / therapeutic use*
Epilepsy, Tonic-Clonic / etiology*
Immunosuppressive Agents / therapeutic use*
Lupus Nephritis / complications*,  drug therapy*
Papilledema / etiology*
Reg. No./Substance:
0/Immunosuppressive Agents; 59865-13-3/Cyclosporine

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