Document Detail

Cerebral ischemic events associated with 'bubble study' for identification of right to left shunts.
MedLine Citation:
PMID:  19498192     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Detection of an intracardiac shunt is frequently sought during the evaluation of patients with cryptogenic ischemic stroke and agitated saline intravenous injection, or "bubble study" (BS), is performed in most cases. We present the first attempt to identify the clinical features in patients who had cerebral ischemic events with BS. METHODS: Using a list serve established by the American Academy of Neurology, a member posted a question regarding the safety of BS in patients with patent foramen ovale. A standardized questionnaire was used to gather data about patients with cerebral ischemic events, details of each case were reviewed, and the findings pooled. RESULTS: Five patients with ischemic complications of BS (all female, aged 42 to 90 years) were identified from 4 institutions, 3 ischemic strokes and 2 transient ischemic attacks. Events occurred either during or within 5 minutes of BS. Early brain MRIs confirmed acute infarction in 3, including one who had transient symptoms. MRI infarct volumes were small, and deficits were mild in those who developed stroke. Diagnostic evaluation revealed a patent foramen ovale alone in one case, a pulmonary arteriovenous malformation in one case, and a patent foramen ovale and/or pulmonary shunt in 3 cases. CONCLUSIONS: Ischemic cerebrovascular complications can occur in patients who undergo BS and are associated with the presence of cardiac or pulmonary shunts. The true incidence and degree of disability remains unknown, and further study is indicated to assess the impact of technical differences in BS methodology. Novel methods to promote physician communication such as the use of electronic list serves may reduce barriers to reporting of drug, technique, or device complications and should be explored to identify rare complications that otherwise will likely go unappreciated.
Jos? R Romero; James L Frey; Lee H Schwamm; Bart M Demaerschalk; Hari P Chaliki; Gunjan Parikh; Robert F Burke; Viken L Babikian
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-06-04
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  40     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-07-27     Revised Date:  2010-04-01    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2343-8     Citation Subset:  IM    
Department of Neurology, Boston University Medical Center, Boston University School of Medicine, Boston, MA 02118, USA.
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MeSH Terms
Aged, 80 and over
Arteriovenous Malformations / ultrasonography*
Echocardiography / adverse effects,  methods
Echocardiography, Transesophageal / adverse effects,  methods
Foramen Ovale, Patent / ultrasonography*
Health Surveys
Ischemic Attack, Transient / etiology*
Microbubbles / adverse effects*
Middle Aged
Stroke / etiology*
Ultrasonography, Doppler, Transcranial / adverse effects,  methods
Comment In:
Stroke. 2010 Apr;41(4):e195; author reply e196   [PMID:  20150552 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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