Document Detail


Cerebral ischemic disease and morphometric analyses of carotid plaques.
MedLine Citation:
PMID:  10466989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerotic carotid plaque morphology and especially, intraplaque hemorrhage are assumed to be related to neurological symptoms. Most researchers have only investigated the incidence of intraplaque hemorrhage in symptomatic and asymptomatic patients. In the present study, the amount of intraplaque hemorrhage is determined in carotid endarterectomy specimens from 33 symptomatic and 14 asymptomatic patients that caused >70% luminal stenosis. The plaque components (fibrosis, lipids, intraplaque hemorrhage, calcification, and intraluminal thrombosis) were quantified as a percentage of the total plaque volume. A high incidence of intraplaque hemorrhage was found in both the symptomatic (94%, 31/33) and asymptomatic (71%, 10/14) patients. The amount of intraplaque hemorrhage was very small within the plaques of the symptomatic (0.39% +/- 0.70%) and asymptomatic (0.37% +/- 1.12%) patients. The plaques of the symptomatic patients contained more fibrosis than lipids (45.62% +/- 14.99% and 20.45% +/- 21.45%, respectively), as did the plaques of the asymptomatic patients (42. 51% +/- 15.28% and 15.46% +/- 15.22%, respectively). Finally, intraluminal thrombosis and calcification were rare. We conclude that the amount of intraplaque hemorrhage was very small and therefore question its direct role in the development of neurological symptoms. In general, the "unstable" plaque contained more fibrosis than lipids.
Authors:
A D Montauban van Swijndregt; H R Elbers; F L Moll; J de Letter; R G Ackerstaff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of vascular surgery     Volume:  13     ISSN:  0890-5096     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-07     Completed Date:  1999-10-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  468-74     Citation Subset:  IM    
Affiliation:
Department of Radiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angiography
Arteriosclerosis / complications,  pathology*,  surgery
Blindness / etiology
Brain Ischemia / etiology*
Calcinosis / pathology
Carotid Artery Thrombosis / pathology
Carotid Stenosis / complications,  pathology*,  surgery
Cerebrovascular Disorders / etiology
Endarterectomy, Carotid
Female
Fibrosis
Hemorrhage / pathology
Humans
Image Processing, Computer-Assisted
Ischemic Attack, Transient / etiology
Lipids
Male
Middle Aged
Ultrasonography, Doppler, Duplex
Chemical
Reg. No./Substance:
0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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