| Cerebral ischemic disease and morphometric analyses of carotid plaques. | |
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MedLine Citation:
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PMID: 10466989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherosclerotic carotid plaque morphology and especially, intraplaque hemorrhage are assumed to be related to neurological symptoms. Most researchers have only investigated the incidence of intraplaque hemorrhage in symptomatic and asymptomatic patients. In the present study, the amount of intraplaque hemorrhage is determined in carotid endarterectomy specimens from 33 symptomatic and 14 asymptomatic patients that caused >70% luminal stenosis. The plaque components (fibrosis, lipids, intraplaque hemorrhage, calcification, and intraluminal thrombosis) were quantified as a percentage of the total plaque volume. A high incidence of intraplaque hemorrhage was found in both the symptomatic (94%, 31/33) and asymptomatic (71%, 10/14) patients. The amount of intraplaque hemorrhage was very small within the plaques of the symptomatic (0.39% +/- 0.70%) and asymptomatic (0.37% +/- 1.12%) patients. The plaques of the symptomatic patients contained more fibrosis than lipids (45.62% +/- 14.99% and 20.45% +/- 21.45%, respectively), as did the plaques of the asymptomatic patients (42. 51% +/- 15.28% and 15.46% +/- 15.22%, respectively). Finally, intraluminal thrombosis and calcification were rare. We conclude that the amount of intraplaque hemorrhage was very small and therefore question its direct role in the development of neurological symptoms. In general, the "unstable" plaque contained more fibrosis than lipids. |
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Authors:
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A D Montauban van Swijndregt; H R Elbers; F L Moll; J de Letter; R G Ackerstaff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of vascular surgery Volume: 13 ISSN: 0890-5096 ISO Abbreviation: Ann Vasc Surg Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-07 Completed Date: 1999-10-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8703941 Medline TA: Ann Vasc Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 468-74 Citation Subset: IM |
Affiliation:
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Department of Radiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angiography Arteriosclerosis / complications, pathology*, surgery Blindness / etiology Brain Ischemia / etiology* Calcinosis / pathology Carotid Artery Thrombosis / pathology Carotid Stenosis / complications, pathology*, surgery Cerebrovascular Disorders / etiology Endarterectomy, Carotid Female Fibrosis Hemorrhage / pathology Humans Image Processing, Computer-Assisted Ischemic Attack, Transient / etiology Lipids Male Middle Aged Ultrasonography, Doppler, Duplex |
| Chemical | |
Reg. No./Substance:
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0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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