Document Detail


Cerebral ischemia: from animal studies to clinical practice. Should the methods be reviewed?
MedLine Citation:
PMID:  11244197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of experimental models of focal cerebral ischemia has allowed for a better knowledge of its pathophysiology and for testing therapeutic strategies. However, most neuroprotective substances giving favorable results in these models have later not been shown to be clinically effective. This could be explained by several reasons. First, the homogeneity obtained in animal models in order to achieve results is not seen in clinical practice in humans, in whom a given pathological condition may show a high variability depending on several parameters. This makes it difficult to achieve groups of patients sufficiently large and homogeneous to obtain valid conclusions in the clinical trials. The lack of agreement between the experimental studies and the clinical practice can also be explained by other reasons, such as the methods of the experimental model itself; by the fact that the methods to assess results in these models are not comparable to those used in clinical practice; by pathophysiological differences between experimental animals and man, and even by the fact that the substances tested have different pharmacological properties in the different species. These disadvantages must not invalidate preclinical neuroprotection studies. Rather, the knowledge of the reasons for divergences with the clinical situation can help to optimize experimental models so that both become actually comparable, and the laboratory results can be confirmed by clinical studies.
Authors:
M Alonso de Leciñana; E Díez-Tejedor; F Carceller; J M Roda
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  11 Suppl 1     ISSN:  1015-9770     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-13     Completed Date:  2001-06-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  20-30     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Affiliation:
Neurology Department, Hospital Ntra. Sra. de Sonsoles, Avila, Spain. malonso@hnss.insalud.es
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Ischemia / physiopathology*,  therapy*
Disease Models, Animal*
Humans
Rats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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