Document Detail

Cerebral injury during paediatric heart surgery: perfusion issues.
MedLine Citation:
PMID:  15376766     Owner:  NLM     Status:  MEDLINE    
Suboptimal neurodevelopmental outcome is common in children who have congenital heart disease. Its aetiology is often multifactorial. This review focuses on the role of cardiopulmonary bypass. Hypothermia is the mainstay of cerebral protection. Low flow and regional low flow are preferred to deep hypothermic circulatory arrest in many situations. Cooling and rewarming, aortopulmonary collaterals, pH, air emboli, the systemic inflammatory response, haematocrit, oxygenation, glucose and ultrafiltration can influence neurodevelopmental outcome. Although no pharmacological agents have been shown to have a beneficial effect on neurodevelopmental outcome in clinical practice in children, animal work on the use of steroids several hours before surgery is encouraging.
Michael J H Scallan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Perfusion     Volume:  19     ISSN:  0267-6591     ISO Abbreviation:  Perfusion     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-09-20     Completed Date:  2005-02-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8700166     Medline TA:  Perfusion     Country:  England    
Other Details:
Languages:  eng     Pagination:  221-8     Citation Subset:  IM    
Department of Anaesthesia, Royal Brompton Hospital, London, UK.
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MeSH Terms
Body Temperature
Brain Injuries / etiology*,  physiopathology,  therapy
Cardiopulmonary Bypass* / adverse effects
Cerebrovascular Circulation*
Cold Temperature
Heart Defects, Congenital / surgery*
Hypothermia, Induced
Oxygen Consumption
Reperfusion* / adverse effects
Reperfusion Injury / physiopathology
Steroids / therapeutic use
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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