| Cerebral infarcts in the setting of eosinophilia: three cases and a discussion. | |
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MedLine Citation:
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PMID: 20937959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe 3 cases of stroke associated with hypereosinophilic syndrome and discuss the pathogenesis of such strokes. DESIGN: Retrospective medical record review. SETTING: University hospital. PARTICIPANTS: Three patients who had strokes temporally correlating with eosinophilia with no other obvious causes of stroke. INTERVENTION: Retrospective review of the hospital course, laboratory data, imaging, treatment, and outcome. RESULTS: All 3 patients had multiple strokes in both hemispheres. Two patients with modest eosinophilia that was controlled quickly had infarcts mostly in arterial border zones and had good outcomes. The third patient with severe and more refractory eosinophilia had a poor outcome. CONCLUSIONS: Cardiac emboli and direct eosinophil toxicity contribute to strokes in hypereosinophilic syndrome. Prognosis is variable with use of anticoagulation and antiplatelet agents but rapid lowering of the eosinophil count results in a better outcome. |
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Authors:
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Hartej S Sethi; James W Schmidley |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of neurology Volume: 67 ISSN: 1538-3687 ISO Abbreviation: Arch. Neurol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2010-10-29 Revised Date: 2012-01-19 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 1275-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. drhartejsingh@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cerebral Infarction / drug therapy, etiology* Diffusion Magnetic Resonance Imaging / methods Eosinophilia / complications*, diagnosis, drug therapy Female Humans Male Middle Aged Retrospective Studies |
| Comments/Corrections | |
Comment In:
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Arch Neurol. 2011 Dec;68(12):1613-4; author reply 1614
[PMID:
22159066
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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