| Cerebral infarction associated with lupus anticoagulants--preliminary report. | |
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MedLine Citation:
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PMID: 6420943 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypercoagulability may contribute to stroke in young adults. Lupus anticoagulants (LA) were identified in six patients (4%) of 145 young adults with cerebral infarction. The clinical features of the 6 patients in this survey plus an additional patient from another institution with LA-associated stroke are presented. Four had systemic lupus erythematosus and 3 had idiopathic LA; all had mild thrombocytopenia. In 2 patients, no other conditions associated with stroke were discovered after thorough evaluation. Recurrent arterial thrombosis occurred in 4 of 7 patients during an average of two years of follow-up. Evidence suggests that inhibition of prostacyclin formation may occur with LA, promoting a prothrombotic state. |
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Authors:
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R G Hart; V T Miller; B M Coull; V Bril |
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17432183 - Echocardiography in stroke patients (with emphasis on cryptogenic stroke). 2191813 - Transient ischemic attacks and ischemic stroke: indications for anticoagulation. 18406433 - Normalisation and increase of abnormal erp patterns accompany recovery from aphasia in ... |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 15 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1984 Jan-Feb |
Date Detail:
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Created Date: 1984-03-09 Completed Date: 1984-03-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 114-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Coagulation Factors / antagonists & inhibitors*, blood Cerebral Infarction / etiology, physiopathology* Female Hemiplegia / etiology, physiopathology Humans Lupus Coagulation Inhibitor Lupus Erythematosus, Systemic / complications, physiopathology* Male Partial Thromboplastin Time Prothrombin Time Recurrence Retrospective Studies Thrombocytopenia / complications, physiopathology Thrombosis / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors; 0/Lupus Coagulation Inhibitor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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