Document Detail

Cerebral infarction associated with lupus anticoagulants--preliminary report.
MedLine Citation:
PMID:  6420943     Owner:  NLM     Status:  MEDLINE    
Hypercoagulability may contribute to stroke in young adults. Lupus anticoagulants (LA) were identified in six patients (4%) of 145 young adults with cerebral infarction. The clinical features of the 6 patients in this survey plus an additional patient from another institution with LA-associated stroke are presented. Four had systemic lupus erythematosus and 3 had idiopathic LA; all had mild thrombocytopenia. In 2 patients, no other conditions associated with stroke were discovered after thorough evaluation. Recurrent arterial thrombosis occurred in 4 of 7 patients during an average of two years of follow-up. Evidence suggests that inhibition of prostacyclin formation may occur with LA, promoting a prothrombotic state.
R G Hart; V T Miller; B M Coull; V Bril
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  15     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:    1984 Jan-Feb
Date Detail:
Created Date:  1984-03-09     Completed Date:  1984-03-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  114-8     Citation Subset:  IM    
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MeSH Terms
Blood Coagulation Factors / antagonists & inhibitors*,  blood
Cerebral Infarction / etiology,  physiopathology*
Hemiplegia / etiology,  physiopathology
Lupus Coagulation Inhibitor
Lupus Erythematosus, Systemic / complications,  physiopathology*
Partial Thromboplastin Time
Prothrombin Time
Retrospective Studies
Thrombocytopenia / complications,  physiopathology
Thrombosis / physiopathology
Reg. No./Substance:
0/Blood Coagulation Factors; 0/Lupus Coagulation Inhibitor

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