| Cerebral hypoperfusion in medication resistant, depressed patients assessed by Tc99m HMPAO SPECT. | |
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MedLine Citation:
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PMID: 8988448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Functional imaging studies generally show decreased cerebral metabolism and perfusion in depressed patients relative to normal controls, although the location of the deficits varies. We used Tc99m HMPAO SPECT to compare cerebral blood flow in medication resistant, depressed patients and a normal control group. HMPAO uptake ratios (adjusted for age) were significantly lower in the depressed patients in the transaxial slices 4 cm and 6 cm above the orbitomeatal line (OML) on the left side. Examining individual regions of interest (corrected for age and multiple testing), we found significantly lower perfusion in the left superior temporal, right parietal and bilateral occipital regions in the patient group. These findings are in limited agreement with previous HMPAO SPECT studies. Methodological differences between studies, particularly variability in adjusting data for age, lead to a divergence in findings. Future research should seek to standardize protocols and data analysis in order to generate comparable results. |
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Authors:
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O Bonne; Y Krausz; M Gorfine; H Karger; Y Gelfin; B Shapira; R Chisin; B Lerer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of affective disorders Volume: 41 ISSN: 0165-0327 ISO Abbreviation: J Affect Disord Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-04-02 Completed Date: 1997-04-02 Revised Date: 2009-09-28 |
Medline Journal Info:
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Nlm Unique ID: 7906073 Medline TA: J Affect Disord Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 163-71 Citation Subset: IM |
Affiliation:
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Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center, Jerusolem 91120, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affective Disorders, Psychotic / drug therapy, psychology, radionuclide imaging Aged Antidepressive Agents / therapeutic use* Bipolar Disorder / drug therapy, psychology, radionuclide imaging Brain Mapping Cerebral Cortex / blood supply*, radionuclide imaging Depressive Disorder / drug therapy, psychology, radionuclide imaging* Dominance, Cerebral / drug effects, physiology Female Humans Male Middle Aged Organotechnetium Compounds / diagnostic use Oximes / diagnostic use Reference Values Regional Blood Flow / drug effects, physiology Technetium Tc 99m Exametazime Tomography, Emission-Computed, Single-Photon* |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Organotechnetium Compounds; 0/Oximes; 100504-35-6/Technetium Tc 99m Exametazime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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