Document Detail


Cerebral histoplasmosis in the azole era: report of four cases and review.
MedLine Citation:
PMID:  12916564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report four cases of cerebral histoplasmosis and discuss features of six additional cases reported in the medical literature in the past 10 years, when azoles have been available for therapy. Most patients with this disease are immunocompromised or have a history that suggests heavy exposure to Histoplasma capsulatum. Fever and other clinical findings of systemic toxicity caused by disseminated histoplasmosis may be absent; 5 of 10 patients did not manifest these findings. Although the mainstay of treatment for central nervous system histoplasmosis remains amphotericin B, 9 of the 10 patients received itraconazole or fluconazole either as initial therapy or after a course of treatment with amphotericin B.
Authors:
Michael Saccente; Richard W McDonnell; Larry M Baddour; M Jane Mathis; Robert W Bradsher
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Southern medical journal     Volume:  96     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-08-14     Completed Date:  2003-08-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  410-6     Citation Subset:  AIM; IM    
Affiliation:
Division of Infectious Diseases, Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. saccentemichael@uams.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Amphotericin B / therapeutic use*
Antifungal Agents / therapeutic use*
Fatal Outcome
Female
Histoplasmosis / diagnosis,  drug therapy*,  physiopathology
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Antifungal Agents; 1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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