Document Detail


Cerebral hemodynamics during coronary artery bypass graft surgery: the effect of carotid stenosis.
MedLine Citation:
PMID:  19540657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carotid stenosis is a frequent coexisting condition in patients undergoing coronary artery bypass graft (CABG) surgery. The impact of carotid stenosis on cerebral perfusion is not fully understood. The purpose of this study was to determine the impact of carotid stenosis on cerebral blood flow velocity in patients undergoing CABG. Seventy-three patients undergoing CABG were prospectively recruited and underwent preoperative Duplex carotid ultrasound to evaluate the degree of carotid stenosis. Intraoperatively, transcranial Doppler ultrasound was used to record the mean flow velocity (MFV) within the bilateral middle cerebral arteries. In addition, during the period of cardiopulmonary bypass, regulators of cerebral hemodynamics such as hematocrit, partial pressure of carbon dioxide and temperature were recorded. The ipsilateral middle cerebral artery mean flow velocity was compared in arteries with and without carotid stenosis using a repeated measures analysis. Seventy-three patients underwent intraoperative monitoring during CABG and 30% (n=22) had carotid stenosis. Overall, MFV rose throughout the duration of CABG including when the patient was on cardiopulmonary bypass. However, there was no significant MFV difference between those arteries with and without stenosis (F=1.2, p=.21). Further analysis during cardiopulmonary bypass, demonstrated that hemodilution and partial pressure of carbon dioxide may play a role in cerebral autoregulation during CABG. Carotid stenosis did not impact mean cerebral blood flow velocity during CABG. The cerebrovascular regulatory process appears to be largely intact during CABG.
Authors:
James L Rudolph; Farzaneh A Sorond; Val E Pochay; Miguel Haime; Patrick Treanor; Michael D Crittenden; Viken L Babikian
Related Documents :
6737507 - Posterior cerebral artery occlusion without hemianopia.
10493377 - Microsurgical anatomy of the temporal lobe: part 1: mesial temporal lobe anatomy and it...
8997907 - Magnetic resonance angiographic evaluation of circulus arteriosus cerebri (circle of wi...
16464367 - Impaired dynamic cerebral autoregulation in middle cerebral artery stenosis.
8055057 - Morphology and development of the arteries of vagina and female external genital organs...
15296917 - Totally endoscopic robotic-guided pulmonary veins ablation: an alternative method for t...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-06-21
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  35     ISSN:  1879-291X     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-11-04     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1235-41     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Blood Flow Velocity
Blood Pressure
Carbon Dioxide / blood
Carotid Stenosis / blood,  physiopathology*,  ultrasonography
Case-Control Studies
Cerebrovascular Circulation*
Chi-Square Distribution
Coronary Artery Bypass*
Coronary Disease / blood,  physiopathology*,  ultrasonography
Hematocrit
Humans
Male
Middle Aged
Middle Cerebral Artery / ultrasonography*
Oxygen / blood
Prospective Studies
Pulsatile Flow
Ultrasonography, Doppler, Transcranial
Vascular Resistance
Grant Support
ID/Acronym/Agency:
AG000294/AG/NIA NIH HHS; AG029861/AG/NIA NIH HHS; AG030967/AG/NIA NIH HHS; AG08812/AG/NIA NIH HHS; K23 AG030967/AG/NIA NIH HHS; K23 AG030967-01A1/AG/NIA NIH HHS; R03 AG029861/AG/NIA NIH HHS; R03 AG029861-02/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
142M471B3J/Carbon Dioxide; S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hepatic transit time analysis using contrast-enhanced ultrasound with BR1: A prospective study compa...
Next Document:  Recovery of skin barrier properties after sonication in human subjects.