Document Detail


Cerebral haemorrhage in a patient with systemic lupus erythematosus and vasculitis treated with intravenous immunoglobulins for a long-time and in absence of other risk factors.
MedLine Citation:
PMID:  21533318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Central nervous system involvement has been reported in up to 60% of patients with systemic lupus erythematosus (SLE). Cerebral vasculitis in SLE is rare and its incidence in post-mortem studies has been documented from 7% to 15% of cases. Cerebral haemorrhage is described in 0.4-7% of cases and it is usually due to inherent or iatrogenic factors (e.g., arterial hypertension, thrombocytopenia or anticoagulation). We report a case of cerebral haemorrhage in a patient with SLE and histologically proven cerebral vasculitis, leading to the death of the patient within 12 months. In the patient presented herein, the cerebral haemorrhage was not correlated to possible known causes of these events, apart from the long-term use of intravenous immunoglobulins. The authors discuss the possible role of intravenous immunoglobulin therapy as pathogenetic factor for cerebral vasculitis in this patient.
Authors:
C Giannitti; A Cerase; C Miracco; A Fioravanti
Related Documents :
21437208 - Brain-derived neurotrophic factor gene val66met polymorphism modulates reversible cereb...
1681668 - Peripheral lymphocyte subpopulations in recurrent aphthous ulceration.
7272208 - Response of alopecia areata to dncb: influence of auto-antibodies and route of sensitiz...
2394138 - Analysis of airflow obstruction by bronchoalveolar lavage following bone marrow transpl...
10588458 - Hemostatic markers in ischemic stroke of undetermined etiology.
21785288 - Pulmonary nocardiosis: computed tomography features at diagnosis.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  La Clinica terapeutica     Volume:  162     ISSN:  1972-6007     ISO Abbreviation:  Clin Ter     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-09-29     Revised Date:  2012-02-27    
Medline Journal Info:
Nlm Unique ID:  0372604     Medline TA:  Clin Ter     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  125-7     Citation Subset:  IM    
Affiliation:
Rheumatology Unit, Department of Clinical Medicine and Immunological Sciences, Pathological Anatomy Section, University of Siena, Italy. chiara.giannitti@libero.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Cerebral Hemorrhage / etiology*
Female
Humans
Immunoglobulins, Intravenous / adverse effects*,  therapeutic use
Immunologic Factors / adverse effects*,  therapeutic use
Lupus Erythematosus, Systemic / complications*
Lupus Vasculitis, Central Nervous System / complications*,  drug therapy*
Risk Factors
Time Factors
Chemical
Reg. No./Substance:
0/Immunoglobulins, Intravenous; 0/Immunologic Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  [Urban stressors and thyroid hormones].
Next Document:  Long-term survival after transarterial chemoembolization for hepatocellular carcinoma.