Document Detail

Cerebral haemorrhage in a patient with systemic lupus erythematosus and vasculitis treated with intravenous immunoglobulins for a long-time and in absence of other risk factors.
MedLine Citation:
PMID:  21533318     Owner:  NLM     Status:  MEDLINE    
Central nervous system involvement has been reported in up to 60% of patients with systemic lupus erythematosus (SLE). Cerebral vasculitis in SLE is rare and its incidence in post-mortem studies has been documented from 7% to 15% of cases. Cerebral haemorrhage is described in 0.4-7% of cases and it is usually due to inherent or iatrogenic factors (e.g., arterial hypertension, thrombocytopenia or anticoagulation). We report a case of cerebral haemorrhage in a patient with SLE and histologically proven cerebral vasculitis, leading to the death of the patient within 12 months. In the patient presented herein, the cerebral haemorrhage was not correlated to possible known causes of these events, apart from the long-term use of intravenous immunoglobulins. The authors discuss the possible role of intravenous immunoglobulin therapy as pathogenetic factor for cerebral vasculitis in this patient.
C Giannitti; A Cerase; C Miracco; A Fioravanti
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  La Clinica terapeutica     Volume:  162     ISSN:  1972-6007     ISO Abbreviation:  Clin Ter     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-09-29     Revised Date:  2012-02-27    
Medline Journal Info:
Nlm Unique ID:  0372604     Medline TA:  Clin Ter     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  125-7     Citation Subset:  IM    
Rheumatology Unit, Department of Clinical Medicine and Immunological Sciences, Pathological Anatomy Section, University of Siena, Italy.
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MeSH Terms
Cerebral Hemorrhage / etiology*
Immunoglobulins, Intravenous / adverse effects*,  therapeutic use
Immunologic Factors / adverse effects*,  therapeutic use
Lupus Erythematosus, Systemic / complications*
Lupus Vasculitis, Central Nervous System / complications*,  drug therapy*
Risk Factors
Time Factors
Reg. No./Substance:
0/Immunoglobulins, Intravenous; 0/Immunologic Factors

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