Document Detail


Cerebral glucose metabolism in dizygotic twin pairs discordant for Alzheimer's disease.
MedLine Citation:
PMID:  18025784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Positron emission tomography (PET) with 2-deoxy-2[(18)F]-fluoro-D-glucose (FDG) can be used to estimate regional cerebral glucose metabolism (rCMRgluc). FDG-PET studies have shown rCMRgluc to be reduced especially in temporal and parietal cortices in Alzheimer's disease (AD). A previous study on monozygotic twins discordant for AD showed that the rCMRgluc of the non-demented twins is reduced significantly in the lateral temporal and parietal cortices compared to unrelated controls. In this study we examined 9 pairs of dizygotic twins discordant for AD with FDG-PET. The rCMRgluc of the demented twins was 16% lower in the prefrontal cortex (p = 0.04), 20% lower in the hippocampus (p = 0.002) and 15% lower in the lateral temporal cortex (p = 0.003) compared to controls. The non-demented twins showed no such reductions on any cortical region compared to unrelated control subjects. This implies that both genes and environment, and not genes alone, are causative in the pathogenesis of AD.
Authors:
Jyri J Virta; Mira Karrasch; Jaakko Kaprio; Markku Koskenvuo; Ismo Räihä; Tapio Viljanen; Juha O Rinne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-16
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  25     ISSN:  1421-9824     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2008  
Date Detail:
Created Date:  2007-12-21     Completed Date:  2008-02-25     Revised Date:  2008-03-24    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  9-16     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Affiliation:
Turku PET Centre, University of Turku, Turku, Finland.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease* / genetics,  metabolism,  physiopathology
Brain / metabolism*,  physiopathology*
Cognition Disorders / diagnosis,  epidemiology
Female
Fluorodeoxyglucose F18 / diagnostic use,  pharmacokinetics
Glucose / metabolism*
Humans
Male
Neuropsychological Tests
Questionnaires
Registries
Twins, Dizygotic / genetics*
Chemical
Reg. No./Substance:
50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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