Document Detail

Cerebral glucose metabolism in corticobasal degeneration comparison with progressive supranuclear palsy using statistical mapping analysis.
MedLine Citation:
PMID:  15936506     Owner:  NLM     Status:  MEDLINE    
This study measured the cerebral glucose metabolism in patients suffering from corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). The aim was to determine if there is a different metabolic pattern using (18)F-labeled 2-deoxyglucose ((18)F-FDG) positron emission tomography (PET). The regional cerebral glucose metabolism was examined in 8 patients diagnosed clinically with CBD (mean age 69.6 +/- 7.8 years; male/female: 5/3), 8 patients with probable PSP (mean age 67.8 +/- 4.5 years; male/female: 4/4) and 22 healthy controls. The regional cerebral glucose metabolism between the three groups was compared using statistical parametric mapping (SPM) with a voxel-by-voxel approach (p < 0.001, 200-voxel level). Compared with the normal controls, asymmetry in the regional glucose metabolism was observed in the parietal, frontal and cingulate in the CBD patients. In the PSP patients, the glucose metabolism was lower in the orbitofrontal, middle frontal, cingulate, thalamus and mid-brain than their age matched normal controls. A comparison of the two patient groups demonstrated relative hypometabolism in the thalamus, the mid-brain in the PSP patients and the parietal lobe in CBD patients. These results suggest that when making a differential diagnosis of CBD and PSP, voxel-based analysis of the (18)F-FDG PET images using a SPM might be a useful tool in clinical examinations.
Rahyeong Juh; Chi-Un Pae; Tae-Suk Kim; Chang-Uk Lee; Boyoung Choe; Taesuk Suh
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-21
Journal Detail:
Title:  Neuroscience letters     Volume:  383     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:    2005 Jul 22-29
Date Detail:
Created Date:  2005-06-06     Completed Date:  2005-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  22-7     Citation Subset:  IM    
Department of Biomedical Engineering, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seocho-Gu, Seoul.
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MeSH Terms
Aged, 80 and over
Brain Mapping*
Case-Control Studies
Fluorodeoxyglucose F18 / metabolism
Glucose / metabolism*
Middle Aged
Neurodegenerative Diseases / complications,  metabolism*,  radionuclide imaging
Positron-Emission Tomography / methods
Supranuclear Palsy, Progressive / complications,  metabolism*,  radionuclide imaging
Reg. No./Substance:
50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

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