| Cerebral embolism following transcatheter aortic valve implantation: comparison of transfemoral and transapical approaches. | |
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MedLine Citation:
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PMID: 21185496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The objective of this study was to compare the incidence of cerebral embolism (CE) as evaluated by diffusion-weighted magnetic resonance imaging (DW-MRI) following transapical (TA) transcatheter aortic valve implantation (TAVI) versus transfemoral (TF) TAVI. BACKGROUND: The TA-TAVI approach avoids both the manipulation of large catheters in the aortic arch/ascending aorta and the retrograde crossing of the aortic valve, and this avoidance might lead to a lower rate of CE. METHODS: This was a prospective multicenter study including 60 patients who underwent cerebral DW-MRI the day before and within the 6 days following TAVI (TF approach: 29 patients; TA approach: 31 patients). Neurologic and cognitive function assessments were performed at DW-MRI time points. RESULTS: The TAVI procedure was performed with the Edwards valve and was successful in all cases but one (98%). A total of 41 patients (68%) had 251 new cerebral ischemic lesions at the DW-MRI performed 4 ± 1 days after the procedure, 19 patients in the TF group (66%) and 22 patients in the TA group (71%; p = 0.78). Most patients (76%) with new ischemic lesions had multiple lesions (median number of lesions per patient: 3, range 1 to 31). There were no differences in lesion number and size between the TF and TA groups. No baseline or procedural factors were found to be predictors of new ischemic lesions. The occurrence of CE was not associated with a measurable impairment in cognitive function, but 2 patients (3.3%) had a clinically apparent stroke within the 24 h following the procedure (1 patient in each group). CONCLUSIONS: TAVI is associated with a high rate of silent cerebral ischemic lesions as evaluated by DW-MRI, with no differences between the TF and TA approaches. These results provide important novel insight into the mechanisms of CE associated with TAVI and support the need for further research to both reduce the incidence of CE during these procedures and better determine their clinical relevance. |
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Authors:
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Josep Rodés-Cabau; Eric Dumont; Robert H Boone; Eric Larose; Rodrigo Bagur; Ronen Gurvitch; Fernand Bédard; Daniel Doyle; Robert De Larochellière; Cleonie Jayasuria; Jacques Villeneuve; Alier Marrero; Mélanie Côté; Philippe Pibarot; John G Webb |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 57 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-27 Completed Date: 2011-03-22 Revised Date: 2011-04-11 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 18-28 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada. josep.rodes@criucpq.ulaval.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Aorta, Thoracic Aortic Valve Stenosis / diagnosis, surgery* British Columbia / epidemiology Diffusion Magnetic Resonance Imaging Echocardiography, Transesophageal Female Femoral Artery Follow-Up Studies Heart Catheterization / adverse effects* Heart Valve Prosthesis Implantation / adverse effects*, methods Humans Incidence Intracranial Embolism / diagnosis, epidemiology, etiology* Male Prospective Studies Quebec / epidemiology Risk Factors Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
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MOP 57745//Canadian Institutes of Health Research |
| Comments/Corrections | |
Comment In:
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Nat Rev Cardiol. 2011 Mar;8(3):120
[PMID:
21475318
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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