| Cerebral effects of hyperglycemia in experimental cardiac arrest. | |
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MedLine Citation:
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PMID: 20562703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the effects of cardiac arrest on cerebral perfusion and oxidative stress during hyperglycemia and normoglycemia. DESIGN: Experimental animal model. SETTING: University laboratory. SUBJECTS: Triple-breed pigs (weight, 22-27 kg). INTERVENTIONS: Thirty-three pigs were randomized and clamped at blood glucose levels of 8.5-10 mM (high) or 4-5.5 mM (normal) and thereafter subjected to alternating current-induced 12-min cardiac arrest followed by 8 mins of cardiopulmonary resuscitation and direct-current shock to restore spontaneous circulation. MEASUREMENTS AND MAIN RESULTS: Hemodynamics, regional near-infrared light spectroscopy, regional venous Hbo2, and biochemical markers (Protein S100beta, troponin I, F2-isoprostanes reflecting oxidative stress and inflammation) were monitored and/or sampled throughout an observation period of 4 hrs. No significant differences were seen in hemodynamics or biochemical profile. The cerebral oxygenation by means of regional near-infrared light spectroscopy was higher in the hyperglycemic (H) than in the normal (N) group after restoration of spontaneous circulation (p < .05). However, tendencies toward increased protein S100beta and 15-keto-dihydro-prostaglandin F2alpha were observed in the H group but were not statistically significant. CONCLUSIONS: The responses to 12-min cardiac arrest and cardiopulmonary resuscitation share large similarities during hyperglycemia and normoglycemia. The higher cerebral tissue oxygenation observed in the hyperglycemia needs to be confirmed and the phenomenon needs to be addressed in future studies. |
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Authors:
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Fredrik Lennmyr; Maria Molnar; Samar Basu; Lars Wiklund |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Critical care medicine Volume: 38 ISSN: 1530-0293 ISO Abbreviation: Crit. Care Med. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1726-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgical Sciences, Section of Anesthesiology and Intensive Care, Section of Cardiothoracic Surgery and Anesthesiology, Uppsala University Hospital, Uppsala, Sweden. lennmyr@surgsci.uu.se |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / blood Blood Glucose / analysis Brain Ischemia / etiology, physiopathology* Cardiopulmonary Resuscitation / methods Cerebrovascular Circulation* Confidence Intervals Disease Models, Animal Heart Arrest / complications*, therapy Hemodynamics / physiology Hyperglycemia / complications* Insulin / blood, pharmacology Oxidative Stress Oxygen Consumption* Random Allocation Swine |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 11061-68-0/Insulin |
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