Document Detail


Cerebral edema.
MedLine Citation:
PMID:  7827479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebral edema continues to plague clinicians caring for patients with acute catastrophic neurologic disease. The defect responsible for the accumulation of water in the brain appears to reflect loss of the strict permeability barrier of the cerebral vasculature. A greater understanding of the physiologic mechanisms at work in the blood-brain barrier have helped target therapies at the vascular interface between the circulating blood and the brain. The mounting evidence which implicates inflammatory events as causally related to the loss of cerebrovascular impermeability supports the clinical strategy of suppression of acute inflammation. Clearly, further advances in the management of cerebral edema will be strongly influenced by the development of specific anti-inflammatory pharmaceuticals.
Authors:
R J Hariri
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurosurgery clinics of North America     Volume:  5     ISSN:  1042-3680     ISO Abbreviation:  Neurosurg. Clin. N. Am.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-23     Completed Date:  1995-02-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9008004     Medline TA:  Neurosurg Clin N Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  687-706     Citation Subset:  IM    
Affiliation:
Division of Neurosurgery, New York Hospital, Cornell Medical Center, New York.
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Reaction / pathology,  physiopathology,  therapy
Animals
Astrocytes / pathology,  physiology
Blood-Brain Barrier / physiology
Brain / blood supply
Brain Edema / pathology,  physiopathology*,  therapy
Capillary Permeability / physiology
Critical Care*
Cytokines / physiology
Endothelium, Vascular / pathology,  physiopathology
Extracellular Space / physiology
Humans
Vasomotor System / pathology,  physiopathology
Water-Electrolyte Balance / physiology
Chemical
Reg. No./Substance:
0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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