Document Detail


Cerebral distribution of white matter lesions in migraine with aura patients.
MedLine Citation:
PMID:  20647177     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: The objective of the study was to compare the cerebral distribution of white matter lesions (WMLs) between migraine patients with different aura symptoms. METHODS: Migraine with aura (MA) patients were consecutively enrolled as part of the Shunt-Associated Migraine (SAM) study. According to clinical symptoms, aura was classified as motor, aphasic, sensory, visual or vertebrobasilar. Standard and FLAIR (fluid attenuated inversion recovery) T(2)-weighted MRI sequences were inspected for WMLs by three independent raters blinded to clinical data. WMLs were assessed in the periventricular areas (PV-WMLs) with the Fazekas scale and in the deep white matter (D-WMLs) with the Schelten's scale. Interobserver agreement was good to excellent (k = 0.64 to 0.96, p < .0001). RESULTS: One hundred and eighty-five patients (77% women) were included. Aura symptoms were classified as visual in 172 (99%) patients, sensory in 76 (42%), aphasic in 54 (30%), motor in 39 (21%) and vertebrobasilar in 17 (9%) patients. One hundred and four patients (57%) exhibited more than one type of aura. D-WMLs were mainly detected in the frontal lobes (86%). There was no association between type of aura and the presence of WMLs in any cerebral location. CONCLUSION: Aura symptoms do not influence the cerebral distribution of WMLs associated with migraine disease.
Authors:
G Rossato; A Adami; V N Thijs; R Cerini; R Pozzi-Mucelli; S Mazzucco; G P Anzola; M Del Sette; L Dinia; G Meneghetti; C Zanferrari;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-10
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  30     ISSN:  1468-2982     ISO Abbreviation:  Cephalalgia     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  England    
Other Details:
Languages:  eng     Pagination:  855-9     Citation Subset:  IM    
Affiliation:
Sacro Cuore Hospital, Italy.
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MeSH Terms
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Investigator
Investigator/Affiliation:
L Pascazio / ; G P Anzola / ; E Morandi / ; M Gamba / ; M Del Sette / ; C Finocchi / ; L Dinia / ; G Sivori / ; C Besta / ; L Caputi / ; E Parati / ; M R Carriero / ; A Adami / ; G Rossato / ; F Marchioretto / ; G Meneghetti / ; G Santarello / ; C Zanferrari / ; G C Manzoni / ; P Torelli / ; M Devetak / ; A Tanzi / ; D Bosone / ; M Diomedi / ; G Leone / ; F Vernieri / ; C Altamura / ; F Tiburzi / ; S Mazzucco / ; E Inchingolo /

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