Document Detail

Cerebral diffusion tensor images in children with tuberous sclerosis: a preliminary report.
MedLine Citation:
PMID:  15029464     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In tuberous sclerosis (TS), tubers usually involve the white matter. Diffusion tensor (DT) images are used to demonstrate white-matter tracts. OBJECTIVE: To determine the changes in DT indices in supratentorial tubers and associated changes in the white-matter tracts adjacent to tubers in patients with TS. MATERIALS AND METHODS: The DT imaging indices, including first, second and third eigenvalues (EVs), apparent diffusion coefficients (ADCs), and fractional anisotropy (FA) in the white-matter lesions of tubers, were assessed in seven patients with TS exhibiting developmental delay and compared with controls. RESULTS: EV1, EV2, EV3, ADC and FA of the white-matter lesions of tubers were significantly different from contralateral unremarkable regions of the brain and from controls (P<0.05). The number of frontal and parietal tubers was significantly negatively correlated with EV1 of the superior longitudinal fasciculi of TS patients (r=-0.60, P =0.04). In addition, TS patients had significantly larger ADCs in the corona radiata and sagittal stratum than the control subjects. EV3s of the inferior longitudinal fasciculus and sagittal stratum were significantly more increased in the TS patients than in the control subjects. CONCLUSIONS: EV1, EV2, EV3, ADC and FA maps are potential tools for demonstrating cerebral white-matter changes owing to TS.
Steven Shinn-Forng Peng; Wang-Tso Lee; Yao Hung Wang; Kou-Mou Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-03-17
Journal Detail:
Title:  Pediatric radiology     Volume:  34     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-15     Completed Date:  2004-09-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  387-92     Citation Subset:  IM    
Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei 100 Taiwan.
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MeSH Terms
Brain / pathology*
Child, Preschool
Magnetic Resonance Imaging / methods*
Statistics, Nonparametric
Tuberous Sclerosis / pathology*

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