Document Detail


Cerebral cortical concentrations of bioamines and their metabolites during arousal and after feeding in the little brown bat (Myotis lucifugus).
MedLine Citation:
PMID:  2605488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentrations of bioamines and their metabolites have been determined in March and April during arousal from hibernation in the cerebral cortex of the little brown bat (Myotis lucifugus). The patterns during arousal for dopamine and serotonin (5-HT) were similar with a significant fall in concentrations by 1 h of arousal, and an inverse relationship with their respective metabolites, 3,4-dihydroxyphenylacetic acid and 5-hydroxyindolacetic acid (5-HIAA). This suggests an acute release and metabolism of these bioamines with onset of arousal. During arousal, cerebral cortical concentrations of norepinephrine (NE) were not significantly changed. Levels of homovanillic acid were markedly depressed during hibernation and rose acutely with arousal. After arousal and 4 days of feeding in April, there was an increase in all bioamines and their metabolites studied except for NE. Of note is the marked decrease in the hibernating level of 5-HT and increase in its metabolite 5-HIAA from March to April, which may herald the natural termination of hibernation. Our results suggest that the brain of hibernators undergoes complex changes in the modulation of neurotransmitter systems which are consistent with both down- and up-regulation of neuronal activity in the maintenance of hibernation and the initiation of the arousal process.
Authors:
W A Bauman; A Hashim; H Sershen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  500     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-02-20     Completed Date:  1990-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  156-60     Citation Subset:  IM    
Affiliation:
Solomon A. Berson Research Laboratory, Veterans Administration MedicalCenter, Bronx, NY 10468.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biogenic Amines / metabolism*
Cerebral Cortex / metabolism*,  physiology
Chiroptera / metabolism*,  physiology
Feeding Behavior / physiology*
Hibernation / physiology*
Seasons
Chemical
Reg. No./Substance:
0/Biogenic Amines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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