| Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques. | |
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MedLine Citation:
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PMID: 1647247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased concentrations of the neuroactive kynurenine pathway metabolites, quinolinic acid (QUIN) and kynurenic acid (KYNA), occur in the CSF of humans infected with the human immunodeficiency virus and macaques infected with retroviruses, including the D/1/California serotype. In the present study, increased activity of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, occurred in cerebral cortex and lung of macaques with clinical SAIDS. Such increases provide a mechanism to accelerate the formation of kynurenine pathway metabolites in both systemic tissues and the central nervous system. |
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Authors:
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K Saito; A Lackner; S P Markey; M P Heyes |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 540 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-07-31 Completed Date: 1991-07-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 353-6 Citation Subset: IM; X |
Affiliation:
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Section on Analytical Biochemistry, National Institute of Mental Health, Bethesda, MD 20892. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebral Cortex / enzymology* Indoleamine-Pyrrole 2,3,-Dioxygenase Kynurenine / metabolism Liver / enzymology Lung / enzymology* Macaca mulatta Reference Values Retroviruses, Simian* Simian Acquired Immunodeficiency Syndrome / enzymology* Tryptophan Oxygenase / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AI20573/AI/NIAID NIH HHS; RR00039/RR/NCRR NIH HHS; RR00169/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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343-65-7/Kynurenine; EC 1.13.11.11/Tryptophan Oxygenase; EC 1.13.11.42/Indoleamine-Pyrrole 2,3,-Dioxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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